摘要
目的为了解亚临床感染弓形虫的孕妇，母婴之间垂直传播情况。方法采用聚合酶链技术（ＰＣＲ）分别检测母婴血弓形虫ＤＮＡ（Ｔｏｘｏ－ＤＮＡ）及羊水Ｔｏｘｏ－ＤＮＡ．结果１．对３０例孕晚期孕妇检测羊水Ｔｏｘｏ－ＤＮＡ与其新生儿血Ｔｏｘｏ－ＤＮＡ，其检测结果无显著差异，Ｐ＞０．０５。２．孕中晚期组孕妇感染弓形虫后，其胎儿感染率明显高于孕早期组，Ｐ＜０．０５。结论孕中晚期孕妇感染弓形虫后，易于传染给胎儿且感染弓形虫为孕妇若能维持到足月分娩，出生的胎儿多为无临床症状的先天性弓形虫病（实验实诊断为阳性），这组胎儿有可能于数年后发生远期并发症；由于羊水易于在孕中晚期获取，故检测羊水Ｔｏｘｏ－ＤＮＡ将有利于先天性弓形虫病的早期诊断及早期治疗，从而控制先天性弓形虫病儿的出生。
Aim To investigate the incidence of congenital toxoplasmosis caused by vertical infection during pregnauey. MethodsTo test ToxoDNA of amnio fluid and blood of newborns on the basis of screening from pregnants with PCR. ResultsWTBZwhen we test Toxo-DNA of amnion fluid and blood of newborns,there was no difference between the result of amnio fluid and that of blood, P >0.05;Vertical infection rate of toxoplasma during the second and third trimester was significantly higher than that of the first trimester, P <0.05. Conclusion Vertical infection occurs easily when pregnants infected toxoplasma during the second and third trimester than the first trimester;the test of Toxo-DNA of amnion fluid should be used for early diagnosis and treatment of congenital toxoplasmosis.
出处
《中国人兽共患病杂志》
CSCD
北大核心
1999年第4期63-64,共2页
Chinese Journal of Zoonoses
关键词
弓形体病
垂直传播
妊娠合并症
预防
Toxoplasma infectionVertical infectionCongenital toxoplasmosisPolymerase chain reaction.
