摘要
目的探讨血管内皮生长因子C(VEGF-C)在大肠癌中的表达及其与大肠癌临床病理学特征的关系。方法运用免疫组织化学(SP法)检测52例大肠癌和18例正常肠黏膜组织中VEGF-C的表达,并比较大肠癌组织VEGF-C的表达与临床病理学特征的关系。结果大肠癌VEGF-C表达率为48%,显著高于正常肠黏膜的表达率11%;癌组织VEGF-C表达率在Duke′s分期A+B期、C+D期分别为26%、66%,在有、无淋巴结转移分别为67%、22%,差异均具有统计学意义(P<0.05)。结论 VEGF-C在大肠癌中的表达与肿瘤临床分期及淋巴结转移密切相关,可能是大肠癌恶性程度评价及判断预后的重要指标。
Objective To investigate the exprssion of vascular endothelial growth factor C（VEGF-C） in colorec-tal carcinoma and explore its correlation with different TNM stages and lymphatic metastasis.Methods The expression of VEGF-C in 52 cases of colorectal carcinoma and 18 cases of normal mucosa were detected by SP immunohistochemistry assay.Results The positive rate of VEGF-C expression in 52 samples of colorectal carcinoma was 48%,significantly higher than that in normal mucosa（11%）.The expression of VEGF-C in colorectal carcinoma was closely related to Duke′s stage and lymph node metastasis,but not related to other clinicopathological status.Conclusion The exprssion of VEGF-C in colorectal carcinoma was closely related to Duke′s stage and lymphtil metastasis,and could be a valuable indicator for assessing tumor′s malignancy and predicting prognosis.
出处
《实用医技杂志》
2011年第1期18-19,共2页
Journal of Practical Medical Techniques
关键词
血管内皮生长因子C
结直肠肿瘤
免疫组织化学
Vascular endothelial growth factor C
Colorectal neoplasms
Immunohistochemistry
