摘要
目的探讨近１０年新生儿败血症病原学的变化特点。方法比较８０年代组与９０年代组新生儿败血症的临床表现、血培养结果、药敏结果的异同点。结果８０年代组以院外感染为主（占８０７７％），９０年代组院内感染增加达５０００％；皮肤、脐部及呼吸道感染始终是主要的感染途径。体温异常、喂养困难、精神差及黄疸、脐部炎症是两组均常见的临床表现。表皮葡萄球菌、金黄色葡萄球菌是主要的致病菌，９０年代耐甲氧西林金黄色葡萄球菌感染率明显上升。青霉素、红霉素及氨苄青霉素敏感率较低；含β内酰胺酶抑制剂的抗生素（优力欣，头孢二、三代）敏感性较高。结论防治医院内获得性感染，是减少新生儿败血症发生的主要措施；随着致病菌的变化，含β内酰胺酶抑制剂的抗生素敏感性较高。
Objective To study the etiological change of neonatal septicemia and direct clinic treatment.Methods The patients with neonatal septicemia were divided into two groups,1983～1988 and 1993～1998.Compare clinic manifestations ,blood culture,and drug sensitivity by statistical methods.Results Infection in hospital was primary in 80s group(80 77%).Infection out hospital made up 50 percent in 90s group.Skin,umbilicus,respiratory tract were primary route of infection.Abnormal temperature,feeding difficulty,listlessness,jaundice,umbilical inflammation were common clinical features.Staphylococcus epidermidis and staphylococcus aureus were primary pathogenic bacteria.MRSE infection rose in 90s group.Penicillin,erythromycin and ampicillin were lower sensitivity,but cephalosporin was higher. Conclusion Treatment and prevention of infection in hospital were primary measure that reduced neonatal septicemia.The antibacterial with anti-β-lactanase was higher sensitivity
出处
《中国实用儿科杂志》
CSCD
北大核心
1999年第7期417-419,共3页
Chinese Journal of Practical Pediatrics
