摘要
目的探讨中国南方汉族人群中表皮生长因子（EGF）基因-61G〉A多态性与肾透明细胞癌（CCRCC）易感性的相关性。方法采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测中国南方汉族295例患者和295例正常人群的EGF．61G〉A基因型，分层分析探讨罹患CCRCC的相关因素。结果与GG型携带者比较，GA型（OR=1．49，95％CI：1．05～2．12）或AA型（1．99，1．12—3．52）携带者发生CCRCC的危险性明显升高。分层分析显示当携带GA或AA型的患者年龄、性别、吸烟以及体质量指数大于23是发生CCRCC的危险因素（年龄：2．48，1．54～4．01；男性：1．56，1．03～2．36；吸烟：2．17，1．23—3．82；体质量指数：1．96，1．28～3．01）。结论EGF-61G〉A多态性可能与我国南方地区汉族人群CCRCC易感性有关。
Objective To investigate the association between the -61G 〉 A polymorphism in the epidermal growth factor （EGF） gene and susceptibility to renal clear cell carcinoma （RCC） in a southern Chinese population. Methods We obtained information on demographic factors by a personal interview. The polymorphism was analyzed by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） using genomic DNA isolated from 295 patients with RCC and 295 age- and sex-matched controis. Stratification analysis by age, sex, smoking, drinking and BMI status was performed. Results As compared with the -61GG genotype, individuals carrying GA genotype （ OR = 1.49, 95% CI = 1.05 - 2. 12） or AA genotype （ 1.99, 1.12-3.52） had an increased risk of RCC. Stratified analysis revealed that the increased risk was more pronounced among young people （2. 48, 1.54-4. 01 ）, males （ 1.56, 1.03- 2. 36）, smokers （2. 17, 1.23-3.82） and those with body mass index larger than 23 （1.96, 1.28-3.01）. Conclusion EGF-61G 〉 A polymorphism may contribute to the etiology of RCC in a southern Chinese population.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2011年第1期108-111,共4页
Chinese Journal of Experimental Surgery
基金
江苏省自然科学基金资助项目（BK2008473）
关键词
肾癌
表皮生长因子
单核苷酸多态性
遗传易感性
Renal carcinoma
EGF
Single nucleotide polymorphism
Hereditary susceptibility
