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p53蛋白在橡胶行业肿瘤高危人群监护中的应用研究 被引量:2

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摘要 1982年IARC首次肯定了橡胶工业某些工种具有致癌性[1],炼胶、硫化等工种癌症发病率显著高于其它工种,特别是消化系统的癌症发病率较高[2]。目前对此尚无早期发现及预防的手段,若能对高危人群进行突变型p53蛋白筛选,将对橡胶行业某些工种高危人群的监...
出处 《中华劳动卫生职业病杂志》 CAS CSCD 1999年第3期168-169,共2页 Chinese Journal of Industrial Hygiene and Occupational Diseases
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参考文献3

  • 1吴自荣,中华医学检验杂志,1997年,20卷,147页
  • 2陈纪刚,肿瘤,1995年,15卷,321页
  • 3励雁峰,肿瘤,1993年,13卷,40页

同被引文献42

  • 1顾祖维.DNA加合物检测在职业医学中的应用[J].职业医学,1994,21(3):50-52. 被引量:1
  • 2IARC.Benzidine.IARC Monographs.1987,(Suppl)7:123.
  • 3Sano T, Smith CL, Cantor CR. Immuno-PCR: very sensitive antigen detection by means of specific antibody-DNA conjugates. Science, 1992,258 : 120-122.
  • 4Zhou HR, Fisher J, Papas TS. Universal immuno-PCR for ultra-sensitive target protein detection. Nucleic Acids Res, 1993,21:6038-6039.
  • 5Edwin RH, Tina MHT, Rolf DJ, et al. High sensitive multianalyte immunoassay using covalent DNA-labelled antibodies and polymerase chain reaction. Nucleic Acids Res, 1995,23:522-529.
  • 6Houghton A, Oyajobi BO, Foster GA, et al. Immortalization of human marrow stromal cells by retroviral transduction with a temperature sensitive oncogene : indentification of bipotential precursor cells capable of directed differentiation to either an osteoblast or adipocyte phenotype.Bone, 1998,22:7-16.
  • 7Lanni JS, Jacks T. Characterization of the p53-dependent postmitotic checkpoint following spindle disruption. Mol Cell Biol, 1998, 18 : 1055-1064.
  • 8Uzoaru I, Rubenstein M, Mirochnik Y, et al. An evaluation of the markers p53 and Ki-67 for their predictive value in prostate cancer. J Surg Oncol, 1998,67 : 33-37.
  • 9Martone T, Airoldi L, Magagnotti C, et al. 4-Aminobiphenyl-DNA adducts and p53 mutation in bladder cancer. Int J Cancer, 1998,75 :512-516.
  • 10Katabami M, Dosaka-Akita H, Honma K, et al. p53 and Bel-2 expression in pneumoconiosis-related pre-cancerous lesions and lung cancers: frequent and preferential p53 expression in pneumoeoniotic bronchiolar dysplasias. In J Cancer, 1998,75 : 504-511.

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