摘要
目的评价糖皮质激素治疗婴幼儿眼部毛细血管瘤的临床效果。设计回顾性病例系列。研究对象2007年11月到2009年4月于北京儿童医院眼科就诊治疗的婴幼儿眼部毛细血管瘤患者33例,其中表层毛细血管瘤12例,深层毛细血管瘤16例,混合型毛细血管瘤5例。方法对所有患者采取口服泼尼松或者瘤体局部注射复方倍他米松治疗。采用眼科多功能测量尺手工测量肿物大小,评价治疗前后血管瘤的大小变化及其有效率。彩色多普勒超声观察血管瘤形态。平均随访(7.42±3.22)个月。主要指标血管瘤的大小、治疗有效率。结果到最后一次随访时,血管瘤的平均体积从治疗前的(2.55±0.35)cm3缩小到治疗后(1.31±0.22)cm3(t=3.705,P=0.001)。表层、深层和混合毛细血管瘤治疗有效率分别为83.4%8、7.5%和40.0%。未发生严重并发症。结论局部注射必要时联合口服糖皮质激素可有效阻止眼部毛细血管瘤的增大并不同程度地减小肿瘤。
Objective To evaluation result of the glucocorticosteriod to treat ocular capillary hemangioma in the infants. Design Retrospective ease series. Participants 33 patients with ocular capillary hemangioma in Beijing Children Hospital. 12 patients with superficial capillary hemangioma; 16 cases with deep capillary hemangioma, 5 cases with mixed capillary hemangioma. Methods The participants received oral prednisone, or betamethasone injection in the location of the tumor. The changes of the volumes of the tumors after treatment were evaluated by the handwork measurement using the rulers. The shape of the ocular capillary hemangioma were observed by color Doppler uhrosound, and follwed up for （7.42±3.22） months. Main Outcome Measures The volumes of the hemangioma, effective rate of the treatment. Results After the treatment using the glucocorticosteriod. The mean volumes of the hemangioma were decreased from （2.55±0.35） cm3 before treatment to （1.31±0.22） cm3 （t=3.705,P=0.001）. The effective rate of the glucocorticosteriod treatment for superficial, deep, and mixed capillary hemangioma was 83.4 %, 87.5%, and 40%, respectively. Adverse effects of them were trivial. Conclusion Glucocorticosteriod treatment for the ocular capillary hemangioma can prevent the growth and minify the volumes of the tumors.
出处
《眼科》
CAS
2010年第6期418-421,共4页
Ophthalmology in China
