摘要
研究氧化槐定碱（Ｏｘｙ）和槐定碱（Ｓｏｐ）对试验性心律失常的作用以及对心肌生理特性的影响．方法：应用各种心律失常模型观察药物对实验性心律失常的作用；离你心肌实验法观察药物对心房生理特性的影响．结果：Ｏｘｙ ５００ ｍｇ·ｋｇ－１ ｉｖ对抗乌头碱，哇巴因和结扎冠状动脉左前降支诱发的室性心率失常，使室性异位搏动数减少（Ｐ＜０．０５），室速持续时间缩短（Ｐ＜０．０１），室颤的发生率由 ７５％减少到１２．５％．其作用与 Ｓｏｐ １０ｍｇ· ｋｇ－１产生的结果相似． Ｏｘｙ ２５０ ｍｇ·ｋｇ－１ ｉｖ对抗氯化钡和氯仿－肾上腺素诱发的心率失常，此作用与 Ｓｏｐ １０ ｍｇ·ｋｇ－１产生的作用相似． Ｏｘｙ， Ｓｏｐ均有提高自律性，降低兴奋性及延长功能不应期的作用．结论：Ｏｘｙ与Ｓｏｐ在等效剂量时，有相似的抗心律失常作用。
AIM: To compare the effects of oxysophoridine (Oxy) and sophoridine (Sop) on experimental arrhythmias and myocardial physiologic properties. METHODS: Arrhythmias were induced by drugs and myocardial ischemia. Physiologic properties were determined on isolated heart atria. RESULTS: Oxy 500 mg·kg-1 (1/6 LD50 ) decreased the incidence of ventricular arrhythmias induced by aconitine (P<0.01 ), increased the threshold dose of ouabain-induced ventricular premature (VP, P<0.05), ventricular tachycardia (VT, P<0.05), ventricular fibrillation (VF, P<0.01), and cardiac arrest, (P<0.01). After iv Oxy 500 mg' kg -- I into the rats with ligation of left anterior descending coroner artery, the total numbers of ectopic beats were decreased (P<0.05), the incidence of VF was lowered, and the duration of VT was shortened (P<0.01). Oxy 250mg·kg-1 (1/13 LD50) iv shortened the duration of arrhythmias induced by BaCl2 (P<0.01) and delayed the onset of arrhythmias induced by chloroform-epinephrine (P< 0.05). Oxy Produced dose-dependent positive inotropic effects in the isolated left atria of guinea pigs, increased the concentration of epinephrine to elicit automaticity in left atria, decreased slightly the excitability, and prolonged the functional refractory period. Sop produced the similar effects on arrhythmias as Oxy. CONCLUSION: Oxy produced the similar anti-arrhythmic effects as Sop did at the equivalent effective dose.
出处
《中国药理学报》
CSCD
1999年第6期517-520,共4页
Acta Pharmacologica Sinica
关键词
槐定碱
氧化槐定碱
心律失常
药理
sophoridine
oxysophoridine
arrhythmia
myocardial contraction
heart atrium
myocardial ischemia
ventricular fibrillation
