摘要
背景:透明质酸为高分子多糖,对骨关节疾病有一定的疗效,近年来已广泛运用。但其作用机制尚不完全清楚,具体疗效尚存争议,因此如何选择合适的患者、合适的药物,以达到提高疗效、减少不良反应,是许多学者一直努力解决的问题。目的:文章就透明质酸在骨关节疾病中的应用情况及其作用机制、安全性、疗效、适应证、不良反应等进行综述。方法:应用计算机检索PubMed数据库(www.pubmed.com),以"hyaluronic acid,hyaluronan,osteoarthritis,fracture"为检索词;应用计算机检索CNKI数据库(www.cnki.net),以"透明质酸,骨折,关节炎"为检索词。结果与结论:最终纳入47篇文献进行分析。透明质酸是一种安全有效的治疗骨关节疾病的药物,其主要作用机制为:覆盖、润滑、缓冲关节软骨应力;减轻炎症关节内反应;促进内源性透明质酸分泌。严格掌握其适应证、选择合适的相对分子质量,能提高患者的症状缓解率、治疗满意度,同时减少医疗资源浪费、不良事件发生。透明质酸治疗的疗程、间隔时间、药物选择等尚存在一定的争议,需进一步研究。
BACKGROUND：Hyaluronic acid,a polymer polysaccharide,has a certain effect on the osteoarthritic diseases and has been widely used.But its mechanism is not entirely clear and the specific effect remains disputes.So how to select appropriate patients,appropriate drugs for getting greater efficacy and reducing side effects has become the aims of many scholars.OBJECTIVE：To review the application,underlying mechanism,safety,efficacy,indications and adverse reactions of hyaluronic acid used for osteoarthritic diseases.METHODS：A computer-based online search of CNKI（www.cnki.net）and PubMed database（www.pubmed.com）was performed with Keywords of ＂hyaluronic acid,fractures,arthritis＂ in Chinese and ＂hyaluronic acid,hyaluronan,osteoarthritis,fracture＂ in English.RESULTS AND CONCLUSION：Finally,47 literatures were included for analysis.Hyaluronic acid is safe and effective for osteoarthritic diseases.The main mechanisms are：coverage,lubrication,cushioning cartilage stress;reducing the intra-articular inflammation;promoting the secretion of endogenous hyaluronic acid.Strict control of its indications and selection of suitable molecular weight hyaluronic acid can increase the symptomatic relief and improve treatment satisfaction,while reducing the medical data waster and adverse events.But some problems such as the course of hyaluronic acid treatment,interval and drug selection are still disputable and require further study.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第47期8835-8839,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
