摘要
目的:观察静脉注射美托洛尔对急性冠状动脉综合征合并室性心动过速(室速)风暴临床疗效及其安全性。方法:将急性冠状动脉综合征合并室速风暴64例患者,随机分为对照组(30例)和美托洛尔组(34例)。对照组患者仅于静脉应用利多卡因或胺碘酮基础上采用电复律治疗,美托洛尔组患者在上述治疗基础上给予静脉注射美托洛尔。结果:美托洛尔组终止反复室速、心室颤动成功率显著高于对照组(91.2%∶30.0%,P<0.05),终止室速及心室颤动所需放电次数显著少于对照组[(4.19±3.27)∶(8.48±5.12)次,P<0.05)],房室传导阻滞的发生率显著高于对照组(20.6%∶6.7%,P<0.05),与对照组低血压的发生率比较,差异无统计学意义(41.2%∶33.3%,P>0.05)。结论:对于急性冠状动脉综合征合并室速风暴患者在常规治疗基础上,及时足量地静脉注射美托洛尔治疗是有效和安全的。
Objective：To evaluate the effect of Metoprolol on ventricular tachycardia storm secondary to acute coronary syndrome.Method：Sixty-four patients with ventricular tachycardia storm secondary to acute coronary syndrome from May 2006 to December 2008 were randomly divided into two groups：control group and Metoprolol intervention group.Patients in control group were treated with Lidocaine or Amiodarone and electric cardiover-sion,while patients in Metoprolol intervention group were intravenously administrated with Metoprolol injection on the basis of the treatment of control group.Result：The success rate of terminating repeated ventricular tachy-cardia or ventricular fibrillation of Metoprolol intervention group was significantly higher than that of control group （91.2%vs 30.0%,P〈0.05）.The necessary discharge times of terminating ventricular tachycardia or ventricular fibrillation in Metoprolol intervention group was considerably decreased than those in control group（[4.19±3.27] vs[8.48±5.12]min,P〈0.05）.The incidence of atrioventricular block in Metoprolol intervention group was markedly increased compared with that in control group（20.6%vs 6.7%,P〈0.05）.No significant difference was found in the incidence of hypotension（41.2%vs 33.3%,P〈0.05）.Conclusion：It is important to be aware of the existence of ventricular tachycardia storm secondary to acute coronary syndrome.On the basis of conventional treatment,intravenous administration of Metoprolol injection is a safe and effective therapy to ventricular tachycardia storm.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2010年第11期816-818,共3页
Journal of Clinical Cardiology
关键词
急性冠状动脉综合征
室性心动过速
心室颤动
美托洛尔
交感风暴
acute coronary syndrome
ventricular tachycardia
ventricular fibrillation
metoprolol
catecholamine storm
