摘要
随着肿瘤治疗的手段不断改进和完善,采用疫苗治疗的方法成为肿瘤治疗的新途径。目前,针对肿瘤治疗的疫苗主要包括以下几种类型:细胞载体疫苗,单克隆抗体疫苗,肿瘤基因疫苗以及肿瘤多肽疫苗等,尤其是肿瘤多肽疫苗,在肿瘤治疗中具有广泛的应用前景。肿瘤多肽疫苗因其特异性高、化学性质稳定、易于制备、无潜在致癌性等优点,受到愈来愈多的关注。很多研究一般都是围绕着黑色素瘤进行的,有些已获得较好的实验结果。多肽疫苗临床治疗一些恶性肿瘤虽已取得一定效果,但尚存在主要组织相容性复合体限制性、免疫原性较弱、免疫应答与临床疗效不尽一致及免疫耐受等问题,因此筛选和开发高效的肿瘤治疗性疫苗还需要更深入的研究。
With the improvement of the means to treat cancer,the vaccine treatment became a new way for curing cancer.At the moment,several types of cancer vaccines exist which include cell carrier vaccine,monoclonal antibody vaccine,tumor gene vaccine and tumor peptide vaccine.Tumor peptide vaccine has a promising future.The peptide vaccines are now drawing more and more attention since they are highly specific,chemically stable,easily prepared and devoid of oncogenic potential.Many researches focused on the clinical treatment of melanoma and some have got promising results.Although peptide vaccines were somewhat effective for some malignant tumors,there existed such problems as HLA type restriction,unsatisfying immunogenicity,inconsistency between intensity of immune response and clinical results,and immune tolerance,which require the further investigation to screen and to develop highly active tumor peptide vaccine.
出处
《药物生物技术》
CAS
CSCD
2010年第6期538-544,共7页
Pharmaceutical Biotechnology
关键词
肿瘤
免疫治疗
多肽疫苗
免疫原性
Tumor
Immunotherapy
Peptide vaccine
Immunogenicity
