摘要
壳聚糖基温度敏感性水凝胶具有原位成胶的特点,广泛应用于组织工程修复和药物释放载体的研究中。近年来围绕壳聚糖及其衍生物温敏水凝胶的研究逐年增多,本文综述了近年来壳聚糖基温敏水凝胶的研究进展及其应用。
Chitosan-based thermosensitive hydrogel could undergo a liquid-solid phase transformation when injected from room temperature environment to human body.Cells,proteins and other drugs could be incorporated into the hydrogel and their in situ fixation or release could be realized.So this hydrogel could be applied to cell transplantation for tissue repair and drug delivery.In this paper,the development of chitosan-based thermosensitive hydrogel is introduced,and its application in tissue engineering and drug delivery are reviewed in detail.
出处
《天然产物研究与开发》
CAS
CSCD
2010年第5期919-927,共9页
Natural Product Research and Development
基金
科技部国际合作重点项目(2008DFA31640)
教育部博士点基金项目(20070423013)
关键词
壳聚糖
甘油磷酸盐
温敏水凝胶
药物释放载体
组织工程
chitosan
glycerophosphate
thermosensitive hydrogel
drug delivery
tissue engineering
