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mTOR抑制剂治疗肾细胞癌的研究进展 被引量：1

Research Progress of mTOR Inhibitors in the Treatment of Renal Cell Carcinoma
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摘要 哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种丝/苏氨酸蛋白激酶,在肾细胞癌(renal cell carcinoma,RCC)的发生、发展过程中起着重要作用。mTOR抑制剂能够抑制mTOR相关信号通路异常引起的癌基因的转化、肿瘤的生长以及肿瘤血管的生成。Temsirolimus和依维莫司(everolimus)被批准应用于临床,为进展期RCC的治疗和预后带来新的曙光。 Mammalian target of rapamycin （mTOR） is a serine / threonine protein kinase, and it plays an important role in the occurrence and development of renal cell carcinoma （RCC）. mTOR inhibitors can inhibit cancer gene transformation caused by abnormal mTOR signaling pathway, tumor growth and tumor angiogenesis. Temsirolimus and everolimus are approved in clinical application, and bring new hope for the prognosis of advanced renal cell carcinoma.
作者 刘旭 张东亮 刘文虎
机构地区 首都医科大学附属北京友谊医院肾内科 首都医科大学肾病学系
出处 《中国全科医学》 CAS CSCD 北大核心 2011年第3期323-324,共2页 Chinese General Practice
关键词 肾细胞癌 MTOR抑制剂 治疗 进展 Renal cell carcinoma mTOR inhibitor Therapy Progress
分类号 R737.11 [医药卫生—肿瘤]
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参考文献19

  • 1Herrmann E, Bierer S, Wulfing C. Update on systemic therapies of metastatic renal cell carcinoma [ J ]. World J Urol, 2010, 28 (3): 303-309.
  • 2Figlin RA. Mechanisms of disease: survival benefit of temsirolimus validates a role for mTOR in the management of advanced RCC [J]. Nat Clin Pract Oncol, 2008, 5 (10) : 601 - 609.
  • 3Pressey JG, Wright JM, Geller JI, et al. Sirolimus therapy for fibromatosis and muhifo- cal renal cell carcinoma in a child with tuber- ous sclerosis complex [J]. Pediatric Blood & Cancer, 2010, 54 (7): 1035-1037.
  • 4Dunlop EA, Tee AR. Mammalian target of ra- pamycin complex 1: signalling inputs, sub- strates and feedback mechanisms [ J]. Cellu- lar Signalling, 2009, 21 (6): 827-835.
  • 5Baldewijns MM, Iris JH, Vermeulen PB, et al. VHL and HIF signalling in renal cell carcinogenesis [J]. J Pathol, 2010, 221 (2): 125-138.
  • 6Kapoor A, Figlin RA. Targeted inhibition of mammalian target of rapamycin for the treat- ment of advanced renal cell carcinoma [ J]. Cancer, 2009, 115 (16): 3618-3630.
  • 7He LZ, Fan C, Gillis A, et al. Co - exist- ence of high levels of the PTEN protein with enhanced Akt activation in renal cell carcinoma [J]. Biochim Biophys Acta, 2007, 1172 (10): 1134-1142.
  • 8Hager M, Haufe H, Kemmerling R, et al. Increased activated Akt expression in renal cell carcinomas and prognosis [J]. Journal of Cel- lular and Molecular Medicine, 2009, 13 (8B): 2181 -2188.
  • 9Robb VA, Karbowniczek M, Klein - Szanto AJ, et al. Activation of the mTOR signaling pathway in renal clear cell carcinoma [J]. J Urol, 2007, 177 (1): 346-352.
  • 10Pantuck AJ, Seligson DB, Klatte T, et al. Prognostic relevance of the mTOR pathway in renal cell carcinoma [ J ]. Cancer, 2007, 109 (11) : 2257 -2267.

同被引文献11

  • 1Kuramochi M,Fukuhara H,Nobukuni T,et al.TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer[J].Nat Genet,2001,27:427-430.
  • 2Murakami Y.Involvement of a cell adhesion molecule,TSLC1/IGSF4,in human oncogenesis[J].Cancer Sci,2005,96:543-552.
  • 3Fukami T,Satoh H,Fujita E,et al.Identification of the Tslc1 gene,a mouse orthologue of the human tumor suppressor TSLC1 gene[J].Gene,2002,295:7-12.
  • 4Pletcher MT,Nobukuni T,Fukuhara H,et al.Identification of tumor suppressor candidate genes by physical and sequence mapping of the TSLC1 region of human chromosome 11q23[J].Gene,2001,273:181-189.
  • 5Heller G,Fong KM,Girard L,et al.Expression and methylation pattern of TSLC1 cascade genes in lung carcinomas[J].Oncogene,2006,25:959-968.
  • 6Houshmandi SS,Surace EI,Zhang HB,et al.Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor[J].Neurology,2006,28:1863-1866.
  • 7Yang YX,Yang AH,Yang ZJ,et al.Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis[J].Int J Gynecol Cancer,2006,16:1868-1872.
  • 8Lung HL,Cheung AK,Xie D,et al.TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma[J].Cancer Res,2006,66:9385-9392.
  • 9Heller G,Geradts J,Ziegler B,et al.Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer[J].Breast Cancer Res Treat,2007,103:283-291.
  • 10Dewan MZ,Takamatsu N,Hidaka T,et al.Critical role for TSLC1 expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo[J].J Virol,2008,82:11958-11963.

引证文献1

中国全科医学
2011年 第3期

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