摘要
目的探讨慢性肾功能衰竭(CRF)患者高瘦素血症与肾小球滤过率(GFR)及炎症之间的相关性。方法对120例不同程度CRF患者进行血清瘦素、GFR、C-反应蛋白(CRP)、IL-6及IL-8检测,观察CRP、IL-6及IL-8与高瘦素血症的相关性。结果不同程度CRF患者与对照者比较,GFR、瘦素、CRP、IL-6及IL-8水平间差异均有统计学意义(P<0.05)。血清瘦素水平与GFR呈负相关(r=-0.23,P<0.001),与BM I呈正相关(r=0.36,P<0.001),而GFR与BM I之间无相关性(r=4.65,P>0.05)。血清瘦素与CRP、IL-6及IL-8之间均呈正相关(r分别为0.54、0.47和0.51,均P<0.001)。结论 CRF患者血清瘦素水平升高与GFR下降所导致的瘦素清除减少有关,全身微炎症反应也可引起高瘦素血症。
Objective To study the relationship between hyperleptindemia, GFR and inflammatory in patients with chronic renal failure. Methods Serum leptin levels, glomernlar filtration rate （ GFR）, CRP, IL -6 and IL -8 of 120 patients having different degrees of renal failure were measured. Then the relationship between CRP, IL -6, IL -8 and serum leptin levels was analyzed. Results The level of serum leptin, CRP, IL -6 and IL -8 varied significantly in middle damaged group and severe damaged group （ P 〈 0. 001 ） , while the level of IL - 6 and IL - 8 in middle damaged group and severe damaged group also varied significantly with that of the control group （P 〈 0. 001 ）. The levels of GFR, serum leptin, CRP, IL- 6 and IL -8 in patients with different stage of kidney failure had statistical differences （ P 〈 0. 05 ）. The level of serum leptin had a negative correlation with GFR （ r = - 0. 23, P 〈 0. 001 ）, and positive correlation with BMI （ r = 0. 36, P 〈 0. 001 ）, while there was no correlation between GFR and BMI （ r = 4. 65, P 〉0. 05 ）. The level of serum leptin had a positive correlation with CRP, IL - 6 and IL- 8 （r = 0. 54, 0. 47,0. 51, P 〈 0. 001 ）. Conclusion The study shows that serum leptin levels have a correlation with the decreased plasma clearance caused by falling GFR. We also learn that ongoing inflammation and body fat increase can stimulates leptin production.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第3期327-328,共2页
Chinese General Practice
关键词
慢性肾功能衰竭
高瘦素血症
肾小球滤过率
炎症
Chronic kidney failure
High serum leptin sydrome
Glomerular filtration rate
Inflammation
