摘要
目的 :探讨 Mg2 + 对脑缺血早期神经元保护机制。方法 :利用阻塞大脑中动脉制造局灶性脑缺血模型 ,观察缺血后 Mg2 +对海马区谷氨酸 ( Glu)含量的影响 ,利用透射电镜观察 Mg2 +对海马 CA1 区神经元超微结构的影响。结果 :大剂量 Mg2 +可显著降低 Glu含量 ,且能减轻缺血后海马 CA1 区神经元的损害。结论 :Mg2 +可能通过降低缺血后 Glu含量达到保护神经元的作用。
Objective:To investigate the protective machanism of magnesium(Mg 2+ ) on the neuron of early stage after focal cerebral ischemia.Methods:The model of focal cerebral ischemia by occluding middle artary in rats was used to investigate the effects of Mg 2+ on volume of glutamate in hippocampal and the microstructure of hippocampal CA 1 neuron.Results:Mg 2+ could significantly decrease the volume of glutamate in hippocampal and attenuate the damage of neuron.Conclusion:Mg 2+ may protect the neuron by reducing the volume of glutamate.
出处
《卒中与神经疾病》
1999年第3期142-144,共3页
Stroke and Nervous Diseases
关键词
硫酸镁
脑缺血
谷氨酸
透射电镜
神经元保护
Magnesium Cerebral ischemia Glutamate Hippocamal CA 1 Electromicroscope
