期刊文献+

CA125作为肿瘤标志物的研究进展 被引量:14

Research progress on CA125 as a tumor marker
下载PDF
导出
摘要 CA125卵巢癌相关抗原发现于1981年。大量研究证明:在健康人和大多数良性疾病患者中,CA125质量甚微;在恶性肿瘤浸润生长和转移的过程中以及一些非肿瘤疾病病情进展时,CA125在各种体液中质量增高。本文对近年来有关CA125作为肿瘤标志物的研究,尤其是口腔癌患者血清和唾液中CA125质量与肿瘤发生、分级和预后的关系作一综述。 CA125 antigen was detected in 1981.Studies have found that the level of CA125 in the healthy people and benign tumor sufferers is low,but high in malignant tumor sufferers,especially when the tumor grows very fast.This article will summarize the CA125 contents in all kinds of malignant tumor sufferers and discuss the relationships between CA125 levels and the existence of tumor,clinical stage and prognosis,especially concentrating on the studies of CA125 levels and oral cancer.
出处 《国际口腔医学杂志》 CAS 2011年第1期106-108,共3页 International Journal of Stomatology
关键词 CA125 肿瘤标志物 恶性肿瘤 CA125 tumor marker malignant tumor
  • 相关文献

参考文献28

  • 1Bast RC Jr, Feeney M, Lazarus H, et al. Reactivity of a monoclonal antibody with human ovarian carcinoma[J]. J Clin Invest, 1981, 68 (5) : 1331-1337.
  • 2Beastall GH, Cook B, Rustin GJ, et al. A review of the role of established tumour markers[J]. Ann Clin Biochem, 1991, 28(Pt 1):5-18.
  • 3Diefanbach CS, Gnjatic S, Sabbatini P, et al. Safety and immunogenicity study of NY-ESO-lb peptide and mon- tanide ISA-51 vaccination of patients with epithelial ova- rian cancer in high-risk first remission[J]. Clin Cancer Res, 2008, 14(9) :2740-2748.
  • 4Lloyd KO, Yin BW, Kudryashov V. Isolation and cha- racterization of ovarian cancer antigen CA 125 using a new monoelonal antibody (VK-8): Identification as a mu- cin-type molecule[J]. Int J Cancer, 1997, 71 (5):842- 850.
  • 5Yin BW, Lloyd KO. Molecular cloning of the CA125 o- varian cancer antigen: Identification as a new muein, blUC16[J]. J Biol Chem, 2001, 276(29):27371-27375.
  • 6O' Brien TJ, Beard JB, Underwood LJ, et al. The CA 125 gene: An extraceUular superstructure dominated by repeat sequences[J]. Tumour Biol, 2001, 22(6):348-366.
  • 7Kaneko SJ, Gerasimova T, Smith ST, et al. CA125 and UQCRFS1 FISH studies of ovarian carcinoma[J]. Gynecol Oneol, 2003, 90(1):29-36.
  • 8赵桓.CA125的临床应用进展[J].中国实用医药,2008,3(19):182-184. 被引量:14
  • 9王若琦.慢性心力衰竭患者血清CA125检测的临床意义[J].实用心脑肺血管病杂志,2009,17(1):73-74. 被引量:9
  • 10Duk JM, Aalders JG, Fleuren GJ, et al. CA 125: A use- ful marker in endometrial carcinoma[J]. Am J Obstet Gynecol, 1986, 155(5) : 1097-1102.

二级参考文献86

共引文献115

同被引文献149

引证文献14

二级引证文献99

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部