摘要
目的：探讨慢性肝病肝血瘀阻与血清肝纤维化标志物之间的关系，认识肝纤维化的中医病因病机本质。方法：采用放射免疫法测定１５２ 例慢性肝病血瘀证和非血瘀证患者及３５ 例对照组的血清透明质酸（ＨＡ）、Ⅲ型前胶原（ｈＰＣⅢ）、Ⅳ型胶原（Ⅳ－Ｃ）。结果：血瘀证和非血瘀证组血清ＨＡ、ｈＰＣⅢ、Ⅳ－Ｃ３项均显著高于对照组，其中血瘀证组血清ＨＡ、ｈＰＣⅢ两项显著高于非血瘀证组。进一步的相关分析表明，血瘀证程度与血清ＨＡ呈密切正相关。结论：肝血瘀阻的程度与肝纤维化密切相关，血清ＨＡ 可作为反映肝血瘀阻程度的良好指标。此外。
Objective: To explore the relationship between liver blood stasis in chronic hepatitis and serum liver fibrosis in order to uncover the mechanism of liver fibrosis.Methods:Hyaluronic acid(HA),human procollagen peptide Ⅲ(hPCⅢ) and Ⅳ collagen(Ⅳ C) in 152 patients of liver disease with or without liver blood stasis and 35 cases of control subjects were measured by using radioimmunoassay.Results:HA,hPCⅢ and Ⅳ C in 152 patients of liver disease are much highar than those in control subjects and HA,hPCⅢ in patients with liver blood stasis much higher than those in patients without liver blood stasis.It was also indicated that the degree of liver blood stasis is positively correlated with HA.Conclusion:HA is a good indicator of the degree of liver blood stasis.And besides liver blood stasis,liver fibrosis is also correlated with other mechanism of liver disease.
关键词
肝血瘀阻
肝纤维化
透明质酸
Ⅲ型前胶原
liver blood stasis
liver fibrosis
hyaluronic acid
human procollagen peptideⅢ
Ⅳ collagen
