摘要
目的:建立高效液相法测定盐酸吗啉胍片中盐酸吗啉胍含量的方法。方法:采用Diamonsil C18(4.6 mm×200 mm,5μm)色谱柱;流动相:甲醇-乙腈-磷酸盐缓冲液(60∶20∶20);检测波长:237 nm;流速:1.0 ml/min。结果:盐酸吗啉胍在20～70μg范围内与峰面积呈良好的线性关系(r=0.999 2),平均回收率为99.90%,RSD=0.69%(n=9)。结论:本方法简便、准确、重现性好,可用于盐酸吗啉胍片中盐酸吗啉胍的质量控制。
Objective： To establish a method for the content determination of Moroxydine Hydrochloride in Moroxydine Hydrochloride Tablets by HPLC. Methods： The Diamonsil C18 （4.6 minx200 mm, 5 μm） column was used. The mobile phases consisted of methanol, acetonitrile and phosphate buffer （60：20：20）, the flow rate was 1.0 ml/min and the detection wavelength was at 237 nm. Results： The linear ranges of Moroxydine Hydrochloride was at 20-70 μg （r=0.999 2）, the av- erage recovery was 99.90% with a RSD of 0.69% （n=9）. Conclusion： The method is fast, reliable, accurate and can be used in the quality control of Moroxydine Hydrochloride in Moroxydine Hydrochloride Tablets.
出处
《中国医药导报》
CAS
2011年第3期58-59,63,共3页
China Medical Herald
关键词
高效液相法
盐酸吗啉胍
盐酸吗啉胍片
含量测定
HPLC
Moroxydine Hydrochloride
Moroxydine Hydrochloride Tablets
Content determination
