摘要
肺炎克雷伯菌是院内感染的常见细菌,碳青霉烯类抗生素对绝大多数β-内酰胺酶稳定,因此一直以来是治疗肺炎克雷伯菌等肠杆菌科细菌感染的最有效抗生素。然而随着碳青霉烯类抗生素的大量使用,全球许多地区出现了碳青霉烯类耐药的肺炎克雷伯菌感染的报道,本文就其流行病学现状、耐药机制及防治措施作一综述。
Klebsiella pneumoniae, one of the most important Gram-negative bacterial pathogens, has caused worldwide concem because of its ability to produce extended-spectrum β-1actamases （ESBLs）. Carbapenems are used to treat patients with infections due to ESBL-producing K. pneumoniae. However, the emergence of carbapenem- resistance Klebsiella pneumoniae （CRKP） has been increasingly reported with the widespread use of carbapenem. This review summarized the status of carbapenem resistance in Klebsiella pneumoniae.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2011年第1期1-6,共6页
Chinese Journal of Antibiotics
关键词
克雷伯菌
碳青霉烯
耐药
感染
Klebsiella pneumoniae
Carbapenem
Resistance
Infection
