摘要
布洛芬和L-抗坏血酸在叔丁醇中,用Novozym 435固定化脂肪酶催化制得布洛芬L-抗坏血酸酯,收率30%,纯度大于98%。热板试验和乙酸扭体试验的结果表明,与布洛芬和布洛芬精氨酸盐相比,布洛芬L-抗坏血酸酯镇痛作用显著。
Ibuprofen L-ascorbic acid ester was synthesized from ibuprofen and L-ascorbic acid in tert-butyl alcohol catalyzed by Novozyme 435 lipase with a yield of 30 % and purity of 98 %. The results of acetic acid writhing test and hot-plate tes showed that ibuprofen L-ascorbic acid ester had significant analgesic activity compared with ibuprofen and ibuprofen arginine salt.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第1期11-13,共3页
Chinese Journal of Pharmaceuticals
