摘要
目的:优选通脉颗粒的提取工艺。方法:在考察通脉颗粒水提液和醇提液的药效的基础上,进一步通过正交试验的方法,以葛根素、阿魏酸、丹酚酸B和丹参酮ⅡA的含量为指标,多指标综合评分法处理数据,优化乙醇浓度、溶剂倍数、提取时间、提取次数4个因素。结果:通脉颗粒最佳提取工艺为8倍量70%乙醇,回流提取3次,每次1.5 h。结论:优选的通脉颗粒提取工艺稳定可行。
Objective： To optimize the extraction technology for anti-myocardial ischemia active component group in Tongmai granules. Method： The extracting conditions were optimized by using orthogonal experiment and pharmacodynamic index. Employing puerarin, fendic acid, tanshinane Ⅱ A, and salvianolic acid B as indexes , the effects of ethanol concentration, solvent volume, ex-traction times and extraction time on the extracting process were investigated. Result： The optimum extraction process was adding 8 times amount of 70% alcohol, refluxing and extracting for 3 times, 1. 5 h each time. Conclusion： This extraction process shows good stability and is available for extracting anti-myocardial Ischemia component group in Tongmai granules.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第2期154-157,共4页
China Journal of Chinese Materia Medica
基金
江苏省中医药领军人才专项(2006)
国家中医药管理局中医药科学技术研究专项(06-07ZQ05)
江苏省中医药局中医药科技技术研究专项(LZ09061)
关键词
通脉颗粒
提取工艺
抗心肌缺血
正交试验
Tongmai granules
extraction process
anti-myocardial ischemia
orthogonal design
