摘要
目的 研究抗氧化剂 β胡萝卜素对染氟大鼠脂质过氧化作用的影响。方法 选健康雄性 Ｗ ｉｓｔａｒ 大鼠２４只，随机分为３组：空白对照组饮用蒸馏水；氟化钠组饮含氟１５０ｍ ｇ／ Ｌ 蒸馏水；补β胡萝卜素组饮含氟１５０ｍ ｇ／ Ｌ 蒸馏水， 同时经饲料给予 β胡萝卜素（２ｇ／ｋｇ）。结果 饮水加氟（１５０ｍ ｇ／ Ｌ）可使大鼠血清、肝、肾组织 Ｌ Ｐ Ｏ 含量显著增加，全血及心、肝、肾组织谷胱甘肽（ Ｇ Ｓ Ｈ）含量下降，超氧化物歧化酶（ Ｓ Ｏ Ｄ）活性下降；饮氟水同时给 β胡萝卜素组血清及肝、肾组织 Ｌ Ｐ Ｏ 含量显著下降，全血及肝组织 Ｇ Ｓ Ｈ 含量升高，肝组织 Ｓ Ｏ Ｄ 活性升高。结论 抗氧化剂 β胡萝卜素对染氟大鼠脂质过氧化具有拮抗作用。
Objective To study the effect of β carotene on lipid peroxidation of rat inducedby fluoride. M ethods 24 healthy W istar rats w ere random ly divided into three groups: controlgroup drank distilled w ater, Na F group drank distilled w ater containing 150m g/ L fluoride,giving β carotene group drank the sam e w ater as Na F group and w ere given β carotene in the food sim ulta┐neously. Results fluoride could significantly increase the content of M D A in the serum ,liver andkindney,and decrease the G S H and S O D levels of blood,heart,liver and kindney,w hile β carotenecould resist these functions w hich had been induced by fluoride. Conclusions β carotene could an tagonize the lipid peroxidation induceed by fluoride.
出处
《中国地方病学杂志》
CAS
CSCD
1999年第5期328-330,共3页
Chinese Jouranl of Endemiology
基金
辽宁省科委科研基金
