摘要
目的 探讨孕妇高碘负荷 对新生儿甲状腺功能及行为神经发育的影响。方法 生活在地方性高碘地区的孕妇２９１名，收集临产前尿样及出生后１５分钟内的脐带血样，并采集不同乡地下水样５份。酸式消化砷铈接触法测定微量碘， Ｅ Ｌ Ｉ Ｓ Ａ 测定脐血 Ｔ Ｓ Ｈ 和 Ｆ Ｔ４，新生儿２０项行为神经测定方法检查行为神经发育。结果 水碘浓度为４９５１±３３．７μｇ／ Ｌ；孕妇尿碘浓度中位数为８５３２μｇ／ Ｌ；脐血 Ｔ Ｓ Ｈ 中位数５００ｍ Ｕ／ Ｌ，其中， Ｔ Ｓ Ｈ＞ ５．００ｍ Ｕ／ Ｌ 的占５０８％ ， Ｔ Ｓ Ｈ≥１０．００ｍ Ｕ／ Ｌ的占１３９％ ； Ｆ Ｔ４为１．４４±０．５１μｇ／ｄ Ｌ，其中 Ｆ Ｔ４＜ ０．８０μｇ／ｄ Ｌ 的为２７％ ；新生儿行为神经发育测定得分为３９０±１１。相关分析显示，孕妇尿碘水平与脐血 Ｔ Ｓ Ｈ 和 Ｆ Ｔ４水平无显著相关关系。新生儿行为神经发育正常。结论 孕妇高碘负荷对新生儿甲状腺功能及行为神经发育未见产生明显影响。
Objective To investigate the effect of m aternal iodine loading on neonatal thyroidfunction and behavioraldevelopm ent. M ethods 291 urinary sam ples w ere collected before parturitionin the pregnant w om en w ho resided in endem ic high iodine areas,and cord blood sam ples w ere collect ed im m ediately after parturition.5 drinking w ater sam ples w ere collected at different villages in theareas. Iodine concentrations of urinary and drinking w ater w ere m easured. T S H and free T4 w ere de term ined using E L I S A (enzym e linked im m unological assay). Behavioral developm ent w ere assessedusing Neonatal Behavioral Neurological Assessm ent ( N B N A). Results The iodine level in drinkingw ater w as 495.1±33.7μg/ L;the m edian urinary iodine of pregnant w om en w as 853.2μg/ L. T S H m e dian of cord sam ples w as 5.00m U/ L,in w hich 50.8% w as over 5.00m U/ L,and 13.9% over 10.00m U/ L.free T4 w as 1.44±0.51μg/d L,in w hich only 2.7% low er than 0.80μg/d L. The total score of N A B A w as 39.0±1.1. The interrelationships betw een m aternal urinary iodine levels and T S H,free T4 values w ere analyzed and no significant relationships am ong them could be observed. The neonatalbehavioral developm ent w as norm al. Conclusions No significant effect on neonatal thyroid functionand behavioral developm ent w ere observed am ong pregnant w om en w ith high iodine loading in thisresearch.[
出处
《中国地方病学杂志》
CAS
CSCD
1999年第5期338-340,共3页
Chinese Jouranl of Endemiology
基金
卫生部地病司资助
关键词
孕妇
碘
甲状腺功能
行为神经发育
Pregnant w om an
Iodine
Neonate
Thyroid function
Behavioral developm ent
