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狼疮性肾炎发病机制研究进展 被引量：1

Study progress to the pathogenesy of lupus nephritis
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摘要 SLE是一种累及多系统、多脏器的非特异性自身免疫性疾病,多种自身抗原参与SLE发生和发展,而且还会引起肾脏受累的一种疾病.本文主要是针对狼疮肾炎的发病机制进行综述,包括抗dsDNA抗体、细胞毒性T细胞以及脱氧核糖核酸酶（DNase1）等致肾炎.抗dsDNA的抗体一般仅限于系统性红斑狼疮,研究可知GBM中染色质免疫沉积物的堆积可能是导致狼疮肾炎的关键.本文以分子和免疫学为基础,综述了以抗体介导LN致病的最新研究,为相关工作人员实验研究及临床治疗LN提供参考帮助.
作者 车文体(综述) 侯玉文(综述) 陈洁晶(综述) 李海燕(综述) 汤冬娥(综述) 戴勇(综述)
机构地区 桂林中国人民解放军第
出处 《国际泌尿系统杂志》 2011年第1期116-120,共5页 International Journal of Urology and Nephrology
关键词 狼疮肾炎
分类号 R593.24 [医药卫生—内科学]
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参考文献29

  • 1Foster MH.T cells and B cells in lupus nephritis.Semin Nephrol,2007,27(1):47-58.
  • 2Crispin J,CLiossis SN,Kis Toth K,et al.Pathogenesis of human systemic lupus erythematsus:recent advances.Trends Mol Med,2010,16(2):47-57.
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  • 5Pekvig OP,Nossent JC.Anti-double-stranded DNA antibodies,nucleosomes,and systemic lupus erythematosus.Arthritis Rheum,2003,48:300-312.
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  • 7Kalaaji M,Fenton KA,Mortensen ES,et al.Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis.Kidney Int,2007,71 (7):664-672.
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二级参考文献7

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国际泌尿系统杂志
2011年 第1期

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