摘要
目的探讨帕罗西汀与马普替林对产后抑郁的临床疗效及安全性。方法将57例产后抑郁患者随机分为帕罗西汀(n=30)和与马普替林(n=27)组,观察治疗6周。采用汉密顿抑郁量表(HAMD)评定疗效,副反应量表(TESS)评定不良反应。结果 HAMD评分显示,与治疗前相比,帕罗西汀组和马普替林分别在治疗2和4周末有极显著性下降(P<0.01);两组患者的显效率分别为76.7%和74.1%,差异无统计学意义(P>0.05);TESS总分评定帕罗西汀组明显低于马普替林组(P<0.01)。结论帕罗西汀与马普替林治疗产后抑郁症疗效相当,但前者的起效更快,不良反应更小,患者的耐受性较好。
Objectives To study the efficacy and safety of paroxetine in the treatment of the postnatal depression.Methods 60 postnatal depression patients were randomly assigned into paroxetine（n=30） and maprotiline（n=27） groups for 6 weeks.Clinical effectiveness were assessed with the Hamilton Depression Scale（HAMD）,and the safety was assessed with treatment emergent symptom scale（TESS）.Results In the paroxetine and maprotiline groups,the score of the HAMD decreased very significantly since the end of the 2st and 4st week compared with pre-treatment（P0.01） separatly.Total clinical efective rate in paroxetine and maprotiline groups were 76.7% 74.1% respectively.No obvious diference was found in clinical eficacy between two groups（P0.05）,obvious diference was found in adverse reactions between two groups with TESS（P0.01）.Conclusion Paroxetine is a safe,efective and rapidly responsive antidepressant to postnatal depression compared to maprotiline.
出处
《当代医学》
2011年第3期145-146,共2页
Contemporary Medicine
关键词
产后抑郁
帕罗西汀
阿米替林
Paroxetine
Maprotiline
Postnatal depression
