摘要
目的:研制马尼地平缓释片,并考察其释药机制。方法:将制备的马尼地平固体分散体及乳糖、聚乙二醇、甲基纤维素分别过80目筛,按处方量称取,按等量递增原则于乳钵中充分混匀,干法直接压片即得。结果:马尼地平缓释片的处方组成为HPMC 60RT8000 40 mg,乳糖40 mg,聚乙二醇6000(PEG6000)40 mg,甲基纤维素(MC)80 mg。结论:该缓释片在8 h内呈现良好的零级释放特征,释放机制为骨架溶蚀机制;该缓释片在24 h内药物的释放更符合Higuchi方程,释放机制为非Fick扩散。
Objective： To prepare manidipine sustained-release tablets and to investigate the release mechanism.Methods： The formulations of manidipine sustained release tablets as well as HPMC,MC,lactose and PEG 6000 were sieved by 80 meshes.The release of manidipine from the sustained-release tablets was observed.Results： The composition of manidipine sustained-release tablet was HPMC 60RT8000 40 mg,lactose 40 mg,PEG6000 40mg and MC 80 mg.The release behavior of the tablets followed zero-order kinetic in 0 to 8 h,and it was properly characterized by the erosion mechanism.Conclusion： The release behavior of the tablets follows Higuchi kinetic in 0 to 24 h,and it is properly characterized by the non-Fick mechanism.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2011年第2期177-179,192,共4页
Chinese Journal of New Drugs
关键词
马尼地平
缓释片
释放度
固体分散体
manidipine
sustained-release tablets
release rate
solid dispersion
