期刊文献+

阿托伐他汀治疗不稳定型心绞痛短期内对同型半胱氨酸影响 被引量:12

Short-time effects on homocysteine level after atorvastatin treatment of unstable angina
下载PDF
导出
摘要 目的:探讨阿托伐他汀治疗不稳定型心绞痛(UAP)短期内对同型半胱氨酸(homocysteine,Hcy)影响。方法:选择68例诊断明确的不稳定型心绞痛患者,随机分成两组,常规组给予拜阿司匹林、氢氯吡格雷抗血小板聚集、低分子肝素抗凝治疗;治疗组在常规组基础上予阿托伐他汀40mg,每晚1次,口服。4周后比较两组同型半胱氨酸变化。结果:与对照组比较,每晚40mg阿托伐他汀能在4周内较明显降低血浆同型半胱氨酸水平,他汀类药物能在短期内降低血中同型半胱氨酸浓度,降低不稳定型心绞痛及动脉粥样硬化危险因素。 Objective To explore the short-time effects on homocysteine level after atorvastatin treatment of unstable angina.Method The 68 patients with confirmed diagnosis of unstable angina(UA)were divided randomly into the two groups,the control group was given aspirin,hydrogen clopidogrel,and low molecular heparin,and the treatment group was given atorvastatin(40 mg,qd oral at night)on the basis of treatment in the control group.The changes of homocysteine level after 4 weeks in the two groups were compared.Results Compared with the control group,the treatment group could lower the homocysteine level obviously in 4 weeks.Conclusion Statin drugs can lower the homocysteine level in a short time,and lower the risk factors in unstable angina and atherosclerosis.
出处 《吉林医学》 CAS 2011年第1期56-57,共2页 Jilin Medical Journal
关键词 阿托伐他汀 不稳定型心绞痛 同型半胱氨酸 Atorvastatin Unstable angina pectoris Homocysteine
  • 相关文献

参考文献5

二级参考文献19

  • 1闵姜勇,叶怀莲,李昌棣.胱氨酸致家兔动脉粥样硬化的实验研究[J].中国循环杂志,1994,9(6):350-353. 被引量:11
  • 2李昌棣,叶怀莲,闵姜勇,邓新,毛亚平.高胱氨酸血症与冠心病关系的临床观察及动物实验[J].中华老年医学杂志,1994,13(1):49-50. 被引量:20
  • 3Graham IM,O'Callaghan P.Vitamins homocysteine and cardiovascular r risk.Cardiovasc Drugs Ther.2002 Sep,16(5):383-389
  • 4Friedman AN,Bostom AG,Selhub J,et al.The kidney and hoomocysteine metabolism.J Am Soc Nephrol.2001 Oct,12(10):2181-2189
  • 5Cook JW,Taylor LM,Orloff SL,et al.Homocysteine and arterial disease.Experimental mechanisms.Vascul Pharmacol.2002 May,38(5):293-300
  • 6De Bree A,Verschuren WM,Kromhout D,et al.Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease.Pharmacol Rev.2002 Dec,54(4):599-618
  • 7Falk E,Zhou J,Moller J.Homocysteine and atherothrombosis.Lipids.2001,36 Suppl:S3-S11
  • 8Vila N,Deulofeu R,Chamoro A,et al.Plasma homocysteine levels in patients with ischemic cerebral infarction.Med Clin(Barc).1998,110:605-608
  • 9Christen WG,Ridker PM.Blood levels of homocysteine and atherosclerotic vascular disease.Curr Atheroscler Rep.2000 May,2(3):194-199
  • 10Den Heijer M,Kostor T,Blom HJ,et al.Hyperhomocysteinemia as a risk factor for deep-vein thrombosis.N Engl J Med.1996,334:759-762

共引文献123

同被引文献69

  • 1李若谷,方唯一,曲新凯,陈晖,杨栓锁,沙慧芳,关韶峰.阿托伐他汀对不稳定性心绞痛患者血清sRAGE和esRAGE水平的影响[J].上海交通大学学报(医学版),2011,31(6):806-808. 被引量:14
  • 2张冬颖,覃数.他汀类药物改善心室重塑的研究进展[J].重庆医学,2004,33(10):1581-1583. 被引量:17
  • 3史立业.阿托伐他汀对不稳定型心绞痛患者炎症因子影响的研究[J].中国心血管病研究,2006,4(4):270-271. 被引量:10
  • 4孟立军,王文英,刁树玲.阿托伐他汀的临床应用[J].实用心脑肺血管病杂志,2007,15(4):325-326. 被引量:11
  • 5中华医学会心血管病学分会.不稳定心绞痛诊断和治病建议.中华心血管病杂志,2006,28:401-403.
  • 6杨书慧.阿托伐他汀在不稳定型心绞痛治疗中的临床疗效分析[J].中国健康月刊,2010,29(2):57-58.
  • 7张玲.阿托伐他汀对不稳定型心绞痛患者几种炎性反应因子的影响[J].中国全科医生,2006,14(3):1153.
  • 8Viljoen A. New approaches in the diagnosis of atherosclero- sis and treatment of cardiovascular disease [ J ]. Recent Pat Cardiovasc Drug Discov,2008,3 ( 2 ) : 84 - 91.
  • 9Nicholls SJ, Borgman M, Nissen SE, et al. Impact of statins on progression of atherosclerosis: rationale and design of SATURN (Study of Coronary Atheroma by InTravascular Ultrasound: effect of Rosuvastatin versus AtorvastatiN) [ J ]. Curr Med Res Opin,2011,27(6) :1 119 -1 129.
  • 10Hill JM, Zalos G, Halcox JP, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk [J]. N Engl J Med,2003,348(7) :593 -600.

引证文献12

二级引证文献57

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部