慢性阻塞性肺病患者治疗前后生活质量及细胞免疫功能变化被引量：14

Changes of the quality of life and immunological functions of patients with chronic obstructive pulmonary disease before and after treatment

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摘要目的：探讨慢性阻塞性肺疾病（COPD）（Ⅲ~Ⅳ级）患者治疗前后生活质量及细胞免疫功能的变化。方法：选择本院2008年7月至2010年7月58例临床诊断COPDⅢ~Ⅳ级的患者,另设28例体检健康者作为正常对照。COPD组给予常规治疗,治疗前后分别检测血清T细胞亚群（CD4＋,CD8＋,CD4＋/CD8＋）并进行生活质量评分（SGRQ）。结果：COPD组患者SGRQ各部分分值及总分值较正常对照组有显著差异,且治疗前后有明显改善（P〈0.01）。正常对照组CD4＋水平、CD4＋/CD8＋值较COPD组明显增高,CD8＋水平则较COPD组显著降低（均P〈0.05）。COPD组急性加重期CD4＋水平、CD4＋/CD8＋值较治疗后显著下降,而CD8＋水平较治疗后显著上升（均P〈0.01）。COPD组患者SGRQ的总分与CD4＋/CD8＋值的变化呈负相关（P〈0.01）。结论：免疫功能失衡可能是COPD患者反复发作加重的原因之一。 Objective： To study the difference of the quality of life and immunological functions of patients with chronic obstructive pulmonary disease（COPD）（level Ⅲ~Ⅳ） before and after treatment.Methods： Fifty-eight elderly patients with COPD（level Ⅲ to Ⅳ） at acute stage were involved.Twenty-eight healthy people were selected as control group.The patients with AECOPD were treated regularly for two weeks.Respiratory Questionairre for quality of life was fulfilled,and T lymphocyte subpopulation and（CD4＋,CD8＋,CD4＋/CD8＋） was measured before and after treatment.Results： The difference of the score of SGRQ was found significantly between healthy and COPD group（P0.01） before and after treatment（P0.01）.The level of CD4＋T cell,and the ratio of CD4＋/CD8＋ in healthy group were higher than those in COPD group,but the level of CD8＋ was lower than that in COPD group（all P0.01）.The level of CD4＋T cell,and the ratio of CD4＋/CD8＋ in AECOPD increased significantly compared with those in the group after treatment,and the level of CD8＋ decreased after treatment（all P0.01）.There was a negative correlation between the total score of quality of life and the ratio of CD4＋/CD8＋（P0.01）.Conclusion： The unbalance of immunological functions may result in recurrence and depravation of COPD.

作者王丽谷伟谭焰毛山陈玉宝

机构地区南京医科大学附属南京市第一医院呼吸科

出处《东南大学学报（医学版）》 CAS 2010年第6期662-665,共4页 Journal of Southeast University(Medical Science Edition)

基金南京市医学科技发展项目(ykk09064)

关键词慢性阻塞性肺疾病生活质量评分 T细胞亚群 chronic obstructive pulmonary diseases the score of the quality of life T-lymphocyte subsets

分类号 R563 [医药卫生—呼吸系统]

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1蔡映云,李倬哲,方宗君.慢性阻塞性肺疾病患者生存质量评估[J].中华全科医师杂志,2004,3(4):225-227. 被引量：163
2ROGERIO R,CL(A)UDIA H C,HEITOR-SIFFERT P S,et al.Induced sputum and peripheral blood cell profile in chronic obstructive pulmonary disease[J].J Bras Pneumol,2007,33(5):510-518.
3MAENO T,HOUQHTON A M.CD8+ T cell are required for inflammation and destruction in cigarette smoke-induced emphysema in mice[J].J Immunol,2007,178:8090-8096.
4ENGSTROM C P,PERSSON L O,LARSSON S,et al.Health-related quality oflife in COPD:why both disease-specific and generic measures should be used[J].Eur Respir J,2001,18:69-76.
5XUEHAI Z,ANEAL S G,RACHEL G,et al.Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease[J].J Immunol,2009,182:3270-3277.