摘要
目的:观察益气活血法为主对慢性肾衰竭(CRF)患者的治疗作用。方法:140例患者随机分为2组各70例,在常规治疗基础上,治疗组给予益气活血法治疗,对照组给予尿毒清颗粒;连续观察3疗程(6月)。结果:治疗组治疗后的症状积分、血脂、纤维蛋白原(Fib)、血清白蛋白(Alb)、前白蛋白(PA)、血红蛋白(Hb)与治疗前相比均有明显改善(P<0.05),且症状积分、TC、LDL-C、Fib与对照组相比有显著性差异(P<0.05);2组治疗前后的血肌酐(Scr)、尿素氮(BUN)、肾小球滤过率(GFR)比较,差异均无显著性意义(P>0.05),但治疗组的Scr、BUN降低幅度、GFR升高幅度与对照组比较,差异均有显著性意义(P<0.05)。治疗组的症状改善总有效率为84.29%,肾功能改善总有效率为80.00%,高于对照组77.14%和61.43%。结论:中医益气活血法对早期CRF患者具有缓解临床症状、稳定肾功能作用,优于对照组;同时也能改善患者营养不良、贫血、高血脂、高凝状态等慢性肾脏病进展的危险因素,后者可能是该疗法延缓CRF的作用机理。
Objective： To observe the therapeutic effect of qi-supplementing and blood-invigorating therapy in treating chronic renal failure（CRF）. Methods： One hundred and forty CRF patients were divided into two groups randomly. Both groups were given routine treatment. Additionally, the treatment group received the decoction of Chinese medicine with the actions of supplementing qi and invigorating blood, and the control group received Niaoduqing Capsule. The treatment covered 3 courses lasting 6 months. Results： Serum levels of total cholesterol（TC）, low density lipoprotein cholesterol （LDL-C）, fibrinogen（Fib）, albumin（AIb）, prealbumin（PA）and hemoglobin（Hb） as well as the symptomatic scores were improved significantly in two groups after treatment（P 〈 0.05 compared with those before treatment）. The improvement of symptomatic scores, TC, LDL-C and Fib in the treatment group was superior to those in the control group（P 〈 0.05）. Serum creatinine （SCr）, blood urea nitrogen （BUN） and glomerular filtration rate （GFR） in two groups before treatment did not differ from those after treatment （P 〉 0.05）. However, the descending of SCr and the ascending of GFR in the treatment group were superior to those in the control group（P 〈 0.05）. The effective rate on relieving symptoms was 84.29% in treatment group and 77.14% in the control group, and the effective rate on improving kidney function was 80.00% in treatment group and 61.43% in the control group. Conclusion： The therapy of supplementing qi and invigorating blood can not only relieve the clinical symptoms and improve kidney function in early CRF patients, but also improve the risk factors of malnutrition, anaemia, hyperlipemia and hypercoagulabale state, which may be its mechanism in postponing the CRF progress.
出处
《新中医》
CAS
北大核心
2011年第2期51-54,共4页
New Chinese Medicine
关键词
肾功能衰竭
中医治法
益气活血法
Renal Failure
TCM Therapy
Qi-Supplementing and Blood-Invigorating Therapy
