摘要
目的已知糖尿病(DM)、高血压(HT)患者的微量蛋白尿(MAB)是冠状动脉疾病(CAD)的危险因素,但是其和CAD病变程度是否相关目前还不清楚。本研究探讨MAB和CAD病变的严重程度直接的关系。方法纳入153例患者,其中男性79例,女性74例,按照冠状动脉造影结果分为CAD组和对照组,按照冠状动脉病变的支数和程度评价CAD的严重程度,比浊法测定MAB量。结果两组之间的HT及血脂紊乱患者比例无显著差异,CAD组患者中MAB发生率高于对照组(62.9%vs8.8%,P<0.01);且和对照组相比,CAD组不同支数MAB增加的比例分别为1支(15.3%vs7.4%,P<0.01),2支组(50%vs22.8%,P<0.05),3支组(29.2%vs19.8%,P<0.01),MAB和CAD严重程度明显相关。结论 CAD合并MAB患者常常有更严重的冠状动脉病变。
Objective To assess the association of microalbuminuria（MAB） with the prevalence and severity of coronary artery disease（CAD）.Methods 153 subjects,79 men and 74 women,aged 45 to 70 years,were classified as CAD-negative and CAD-positive according to the results of coronary angiography.The severity of CAD was scored on the basis of the number and the extent of lesions within the coronary arteries.Urine albumin excretion was measured in 24h urine samples by method of nephelometry.Results CAD occurred more frequently in males than in females and in smokers than in non-smokers.There were no significant differences in the prevalence of hypertension and hypercholesterolemia between two groups.MAB was more prevalent in CAD-positive patients than in controls（62.9% vs.8.8%,P0.001）.Patients with MAB compared with the controls had increased prevalence of one（15.3%vs.7.4%,P0.001）,two（50% vs.22.8%,P0.001）,and three vessel disease（29.2% vs.19.8%,P0.001）.MAB exhibited a significant correlation with the severity of CAD（r=0.40,P0.001）.Conclusion sPatients with MAB have more severe angiographically detected CAD than those without MAB.The results indicate that MAB exhibits a significant association with the presence and severity of CAD.
出处
《中国医药指南》
2011年第3期17-18,共2页
Guide of China Medicine
关键词
冠状动脉疾病
糖尿病
微量蛋白尿
Coronary artery disease
Diabetes mellitus
Microalbuminuria
