摘要
目的 探讨近16年解放军总医院溃疡性结肠炎（UC）的临床特征的变化特点.方法 总结分析解放军总医院1994至2009年期间确诊并住院治疗的UC患者的临床资料.结果 自1994-2009年共有525例患者诊断为UC,中位发病年龄42岁.在发病部位中,12.4%（65/525）为直肠,25.7%（135/525）为直乙状结肠,21.3%（112/525）为左半结肠,33.3%（175/525）为全结肠,7.2%（38/525）为结肠广泛受累.按照发病分型,18.1%（95/525）为初发型,69.0%（362/525）为慢性复发型,9.7%（51/525）为慢性持续型,3.2%（17/525）为急性暴发型.按照病情程度,42.1%（221/525）患者诊断为轻度,30.9%（162/525）为中度,27.0%（142/525）为重度.60岁以上的患者近5年UC发病率明显增高（P＜0.05）.与30岁以下的UC患者相比,60岁以上的UC患者多为男性,病变多位于直肠、直乙结肠,且症状轻,复发率更低（P＜0.01）.结论 近16年来我院UC住院患者的临床特征呈现总体发病率增高、黏液脓血便及贫血症状减少、老年患者增多的变化趋势,UC患者总体的病情程度、病情分期没有明显变化.老年UC患者多为男性,病变多位于直肠、直乙结肠,且症状轻,复发率较年轻组UC患者低.
Objective To investigate the clinical characteristics and chronological change of ulcerative colitis（UC） in the Chinese PLA General Hospital in near 16 years. Methods Patients diagnosed with UC during the period from 1994 to 2009 in the Chinese PLA General Hospital were registered and their clinical profiles were analyzed. Results From 1994 to 2009, of 525 patients diagnosed with UC, with a median onset age of 42 years. The predominant form of UC was extensive colitis, which affected almost 33.3% （175/525）, left-sided colitis was present in 21.3% （112/525） and rectum was present in 12.4%（65/525）. The chronic relapsing type of UC was the most common （69.0%, 362/525 ）, followed by the initial onset type （18. 1%, 95/525 ）, chronic continuous type with intermittent exacerbations （9.7%,51/525）, and acute fulminant type （3. 2%, 17/525 ）. Two hundred and twenty-one patients （42. 1%,221/525） were graded as mild, 162 （30.9% , 162/525） as moderate, and 142（27.0%, 142/525） as severe UC. The proportion of mild colitis and rectum was significantly higher in patients with an onset age of over 60 years, compared with those with an onset age of less than 30 years（ P 〈0. 05 ）. The proportion of UC patients with old age onset （ P 〈 0. 05 ）, male sex （ P 〈 0. 01 ）, mild colitis （ P 〈 0. 01 ）, rectum （ P 〈0. 01 ） , relapse-free type （ P 〈 0. 01 ） demonstrated a chronological increase from 1994 to 2009.Conclusions The distinctive clinical features and chronological change were seen in UC patients in recent years. Compare to those with an onset at less than 30 years, the proportion of mild colitis and rectum was significantly larger in patients with an onset at over 60 years of age, and the proportion of UC patients with old age onset, male sex, mild colitis, rectum, relapse type were less.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2011年第1期40-43,共4页
Chinese Journal of Internal Medicine
关键词
结肠炎
溃疡性
疾病特征
年代变化
Colitis, ulcerative
Disease attributes
Chronological change
