期刊文献+

氟脱氧葡萄糖PET-CT常规及双时相显像检测食管癌术后复发转移的价值

Value of regular and dual-time-point FDG PET/CT imaging in detecting recurrence and metastasis after a curative esophagectomy in esophageal carcinoma
原文传递
导出
摘要 目的 评价氟脱氧葡萄糖(FDG)PET-CT常规及双时相显像在监测食管癌术后复发转移中的应用价值.方法 回顾分析食管癌术后临床怀疑复发转移而行FDG PET-CT检查的48例患者临床资料,根据细胞学、病理或随访结果分析FDG PET-CT检查结果.两样本率比较采用Fisher's精确概率法检验.结果 48例患者中位随访21.5个月,34例出现复发转移,确定复发转移灶61处.FDG PET-CT常规显像对全部病灶诊断的敏感性、特异性和准确性分别为93.44%、74.29%和86.46%;对局部复发和区域淋巴结转移的敏感性、特异性、准确性分别为91.67%、57.14%、78.95%和90.48%、77.78%、84.62%.FDG PET-CT双时相显像诊断局部复发+区域淋巴结转移的敏感性、特异性、准确性均高于常规显像,分别为96.97%∶90.90%(P=0.613)、96.00%∶72.00%(P=0.049)、96.55%∶82.76%(P=0.029).结论 FDG PET-CT常规显像虽然检测食管癌术后局部复发及区域淋巴结转移的特异性和准确性较低,但仍是检测其术后复发转移的有效手段;双时相显像较常规显像更具优势,可有效提高检测的特异性及准确性. Objective To evaluate the clinical value of regular and dual-time-point 18-fluorodeoxyglucose positron emission tomography-CT(FDG PET/CT)imaging for recurrence and metastasis in esophageal carcinoma(EC)after curative esophagectomy. Methods A retrospective study was done on 48 patients received curative esophagectomy, who underwent FDG PET/CT scans to detect doubtful recurrent or metastatic lesions. The diagnostic accuracy of FDG PET-CT was assessed with the help of pathological findings as well as clinical or follow-up data. Using Fisher's Exact Test from SPSS 11.5 to analyze the data.Results Of the 48 patients, after a median follow-up of 21.5 months, 61 sites of local and regional recurrence or metastasis were finally confirmed in 34 patients. The sensitivity, specificity and accuracy of regular FDG PET/CT imaging in detecting recurrence of all sites were 93.44%, 74.29% and 86.46%respectively. The specificity and accuracy of local recurrence and regional metastasis were 57.14% ,78.95% and 77.78% ,84.62%, respectively. The sensitivity, specificity and accuracy of dual-time-point FDG PET/ CT imaging in detecting local and regional recurrence(96.97% ,96.00% and 96.55%)were higher than those of regular FDG PET/CT(90.90%, 72.00% and 82.76%)and there were significant differences of specificity and accuracy(P = 0.049, P = 0.029). Conclusions Regular FDG PET/CT imaging is highly effective in detecting recurrence and metastasis in EC patients after curative esophagectomy despite the low specificity and accuracy. Dual-time-point FDG PET/CT imaging can elevate the specificity and accuracy.
出处 《中华放射肿瘤学杂志》 CSCD 北大核心 2011年第1期36-39,共4页 Chinese Journal of Radiation Oncology
关键词 食管肿瘤 肿瘤复发 局部 肿瘤转移 体层摄影术 发射型计算机 氟脱氧葡萄糖 双时相显像 Esophageal neoplasms Neoplasm recurrence, local Neoplasm metastasis Tomography, emission-computed Fluoro-deoxyglucose Dual-time-point imaging
  • 相关文献

参考文献15

  • 1Shimada H,Kitabayashi H,Mabeya Y,et al.Treatment response and p rognosis of patients after recurrence of esophageal cancer.Surgery,2003,133:24-31.
  • 2Araki K,Ohno S,EgashiraA,et al.Pathologic features of superficial esophageal squamous cell carcinoma with lymph node and distal metastasis.Cancer,2002,94:570-575.
  • 3王玉祥,祝淑钗,李任,邱嵘,李娟.食管癌术后区域性复发的放疗[J].中华放射肿瘤学杂志,2005,14(2):86-89. 被引量:23
  • 4王鹤皋,戴建平,邱志钧,丁悌.根治性放疗后食管癌复发的手术切除和再程放疗的比较[J].中华放射肿瘤学杂志,1996,5(1):2-4. 被引量:29
  • 5李涛,于长华,彭进.食管癌术后纵隔转移灶三维适形放射治疗的疗效[J].中华放射肿瘤学杂志,2004,13(4):268-269. 被引量:31
  • 6Raoul JL,Ie Prise E,Meunier B,et al.Combined radiochemotherapy for postoperative recurrence of oesophageal cancer.Gut,1995,37:174-176.
  • 7Toh Y,Oki E,Minami K,et al.Follow-up and recurrence after a curative esophageetomy for patients with esophageal cancer:the first indicators for recurrence and their prognostic values.Esophagus,2010,7:37-43.
  • 8Teyton P,Metges JP,Atmani A,et al.Use of positron emission tomography in surgery follow-up of esophageal cancer.J Gastrointest Surg,2009,13:451-458.
  • 9Flamen A,Lerut E,van Cutsem E,et al.The utility of positron emission tomography for diagnosis and staging of recurrent esophageal carcinoma.J Thorac Cardiovase Surg,2000,120:1085-1092.
  • 10于金明,邢力刚,杨国仁.^(18)F-脱氧葡萄糖PET用于制定肿瘤放射治疗计划研究进展[J].中华放射肿瘤学杂志,2004,13(2):133-136. 被引量:20

二级参考文献39

  • 1李涛,于长华,彭进.食管癌术后纵隔转移灶三维适形放射治疗的疗效[J].中华放射肿瘤学杂志,2004,13(4):268-269. 被引量:31
  • 2Ling CC, Humm J, Larson S, et al. Towards multidimensional radiotherapy (MD-CRT): biological imaging and biological conformality.Int J Radiat Oncol Biol Phys, 2000,47:551-560.
  • 3Erdi YE, Rosenzweig K, Erdi AK, et al. Radiotherapy treatment planning for patients with non-small cell lung cancer using positron emission tomography (PET). Radiother Oncol, 2002,62: 51-60.
  • 4Kiffer JD, Berlangieri SU, Scott AM, et al. The contribution of 18F-fluoro-2-deoxy-glucose positron emission tomographic imaging to radiotherapy planning in lung cancer. Lung Cancer, 1998 , 19:167-177.
  • 5Nestle U, Walter K, Schmidt S, et al. 18F-deoxyglucose positron emission tomography (FDG-PET) for the planning of radiotherapy in lung cancer: high impact in patients with atelectasis. Int J Radiat Oncol Biol Phys, 1999,44:593-597.
  • 6Munley MT, Marks LB, Scaffone C, et al. Multimodality nuclear medicine imaging in three-dimensional radiation treatment planning for lung cancer: challenges and prospects. Lung Cancer, 1999, 23: 105-114.
  • 7Graud P, Grahek D, Montravers F, et al. CT and 18F-deoxyglucose (FDG) image fusion for optimizations of conformal radiotherapy of lung cancers. Int J Radiat Oncol Biol Phys, 2001,49:1249-1257.
  • 8Mah K, Caldwell CB, Ung YC, et al. The impact of (18)FDG-PET on target and critical organs in CT-based treatment planning of patients with poorly defined non-small-cell lung carcinoma: a prospective study. Int J Radiat Oncol Biol Phys, 2002,52: 339-350.
  • 9Schmuecking M, Plichta K, Lopatta EC, et al. Image fusion of 18FDG PET and CT, is there a role in 3D-radiation treatment planning of nonsmall cell lung cancer? Int J Radiat Oncol Biol Phys, 2000, 48 Suppl:130.
  • 10Caldwell CB, Mah K, Ung YC, et al. Observer variation in contouring gross tumor volume in patients with poorly defined non-small-cell lung tumors of CT: the impact of 18FDG-hybrid PET fusion. Int J Radiat Oncol Biol Phys, 2001,51:923-931.

共引文献99

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部