摘要
目的运用静息态脑功能磁共振成像局部一致性(ReHo)方法探索网络成瘾(internet addiction,IA)青少年静息态脑功能的变化。资料与方法采用3.0TMRI对18名IA青少年和18名年龄、性别相匹配的正常对照组进行静息态脑功能扫描。采用静息态功能磁共振数据处理工具包(DPARSF)进行数据预处理和ReHo分析,采用双样本t检验分析,P<0.001,体素个数>10个被认为有统计学意义。结果在静息状态下,与正常组比较,IA组以下脑区ReHo降低有统计意义,包括右侧海马旁回、右侧舌回、左侧脑岛、右侧中央后回和左侧顶下小叶。结论 IA青少年静息状态下脑默认网络与正常对照组存在差异,这可能为研究IA的发病机制提供新的依据。
Objective In the study,we used a regional homogeneity（ReHo） method to investigate Internet adolescents（IA） related modulations of neural activity in the resting state. Materials and Methods FMRIs were acquired in 18 adolescents with IA and 18 age-,sex-and education-matched normal adolescents. The data preprocessing and analysis were performed by Data Processing Assistant for Resting-State fMRI（DPARSF）.A two-sample t-test was used to examine the difference of ReHo between the two groups（P0.001,voxel size10）. Results Compared with healthy controls,IA adolescents had lower ReHo in some areas including right parahippocampa gyrus,right posterior cingulated,left insula,right postcentral gyrus,left superior parietal lobule. Conclusion Our findings suggested that resting-state brain function changes were present in IA adolescents,and this finding may provide a new insight into the pathogenesis of IA.
出处
《临床放射学杂志》
CSCD
北大核心
2011年第1期7-10,共4页
Journal of Clinical Radiology
基金
上海交通大学医学院重点学科资助项目,上海市重点学科建设资助项目(项目编号S30203)
关键词
网络成瘾
功能磁共振
静息态
局部一致性
Internet addiction Functional magnetic resonance Resting-state Regional homogeneity
