摘要
目的探讨食物过敏与溃疡性结肠炎的关系。方法用ELISA法检测121例溃疡性结肠炎患者及85例健康对照者的血清食物特异性抗体IgG(sIgG)水平。将血清食物特异性抗体检测阳性的溃疡性结肠炎患者(n=79)随机分为饮食控制组(n=40)和非饮食控制组(n=39)。饮食控制组患者给予常规治疗并忌食IgG阳性食物,非饮食控制组患者仅给予常规治疗,不予饮食干预。随访2个月观察其临床疗效。结果 121例溃疡性结肠炎患者中出现食物sIgG阳性者达79例,阳性率为65.29%。85名健康对照者出现食物sIgG阳性者15例,阳性率为17.65%;两组阳性率比较,差异有统计学意义(P<0.01)。饮食控制组2个月总有效率达85.0%,非饮食控制组2个月总有效率43.6%,二组比较,差异有统计学意义(P<0.05)。结论剔除溃疡性结肠炎患者饮食中的IgG阳性食物,有助于提高临床疗效,血清食物特异性抗体IgG水平升高与溃疡性结肠炎发病有关。
Objective To investigate the relationship between ulcerative colitis （UC） and food allergy. Methods The serum food allergen-specific IgG （slgG） level was detected in 121 patients with ulcerative colitis and 85 health controls by enzyme-linked immunosorbent assay （ELISA）. The UC patients who had slgG-positivity （n = 79） were divided into the diet control group（ n = 40）and the non-diet control group（ n = 39 ）. Patients in the diet control group were treated with 5-aminosalicylic acid and prednisone, with their daily diets eliminating the IgG-positive food. Patients in the non-diet control group were treated with 5-aminosalicylic acid and prednisone, without diet restriction. After two months of follow-up, the efficacy in the diet control group and the non-diet control group was observed and compared. Results The slgG-positive rate in 121 UC patients was 65.29% （79/121）, while in the 85 health controls was 17.65% （15/ 85 ）. and there was a great statistical significance between the two groups（ P 〈0.01 ）. The total response rate in the diet control group was 85.0% during two months of follow-up, while that in the non-diet control group was 43.6%, and there was a significant difference between the two groups （P 〈 0.05 ）. Conclusions Eliminating the IgG-positive food from UC patients＇ diet would be helpful to improve the therapeutic efficacy. High level of serum food allergen-specific IgG may be relative to incidence of UC.
出处
《山东大学学报（医学版）》
CAS
北大核心
2011年第1期86-89,共4页
Journal of Shandong University:Health Sciences
基金
山东省自然科学基金资助项目(No.Y2006C135)
