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载脂蛋白A5基因-12238T／C多态性与新疆维吾尔族冠心病的相关性 被引量：4

Association of apolipoprotein A5 gene polymorphism with coronary heart disease in Uygur population of Xinjiang
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摘要 目的 研究载脂蛋白A5（apolipoprotein A5，APOA5）-12238T／C多态性与新疆维吾尔族冠状动脉粥样硬化性心脏病（简称冠心病）及血脂水平的相关性。方法采用聚合酶链反应-限制性片段长度多态性方法，对344例冠心病患者和408例同期入院冠状动脉造影结果阴性的患者（对照组）APOA5基因-12238T／C多态性进行检测，同时进行血脂水平的测定。结果APOA5基因-12238T／C的3种基因型在冠心病组的分布频率分别为：TT型50．00％，TC型43．31％，CC型6．69％；在对照组的分布分别为：TT型39．95％，TC型45．10％，CC型14．95％，两组基因型分布差异具有统计学意义（P〈0．01）。通过Logistics回归校正了年龄、性别、吸烟史、血脂、高血压、糖尿病史等影响因素后，CC基因型的个体患冠心病的风险是TT型的0．328倍（OR=0．328，95％CI：0．154～0．700）。冠心病组-12238T／C基因型亚组间的甘油三酯水平的差异有统计学意义（P〈0．05），CC及TC基因型较TT型有更低的甘油三酯水平。结论APOA5基因-12238T／C多态性对新疆维吾尔族人血清甘油三酯水平有影响，并且与冠心病的发生有一定的相关性，CC基因型可能是冠心病发生的一个保护因素。 Objective To investigate the association of the 12238T/C polymorphism of apolipoprotein A5 （APOA5） gene with coronary heart disease （CHD） and the influence of serum lipid levels in Chinese Uygur population of Xinjiang. Methods The -12238T/C polymorphism ofAPOA5 gene in 344 patients with CHD and 408 controls was analyzed by polymerase chain reaction restriction fragment length polymorphism, the serum lipid levels were detected as well. Results The frequencies of CC, TC and TT genotype were 6.69%, 43.31% and 50.00% in the CHD group, while they were 14. 95%, 45. 10% and 39.95 % in the control group. There was significant difference in the distribution of genotypes between the two groups （P〈 0. 01）. Logistic regression analyses adjusted for age, gender, smoking, serum total cholesterol, presence of hypertension and diabetes revealed that individuals carrying CC genotype had an increased risk of CHD compared with TT genotype （OR=0. 328,95 % CI： 0. 154-0. 700）. There was also significant difference in serum triglyceride level in genotypes between these two groups （P〈0.01）. Patients in CHD group who carried CC and TC genotypes had lower serum triglyceride level than the TT genotype carriers. Conclusion The - 12238T/C polymorphism of APOA5 gene has influence on the serum triglyceride level in Uygur population of Xinjiang. This polymorphism might be associated with development of CHD, and the CC genotype might be a protective factor in the development of CHD.
作者 袁山 马依彤 谢翔 杨毅宁 付真彦 马翔 李晓梅 向阳 刘芬 陈邦党
机构地区 新疆医科大学第一附属医院心脏中心冠心病科
出处 《中华医学遗传学杂志》 CAS CSCD 北大核心 2011年第1期73-77,共5页 Chinese Journal of Medical Genetics
基金 新疆自治区重大科技专项课题（200733146-3）
关键词 载脂蛋白A5 甘油三酯 冠状动脉粥样硬化性心脏病 遗传多态性 apolipoprotein AS triglyceride coronary heart disease genetic polymorphism
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献14

  • 1Cullen P. Evidence that triglycerides are an independent coronary heart disease risk factor. Am J Cardiol, 2000,86: 943-949.
  • 2Pennacchio LA, Olivier M, Hubacek JA, et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science, 2001, 294: 169- 173.
  • 3van der Vliet HN, Sammels MG, Leegwater AC, et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. Biol Chem, 2001,276: 44512- 44520.
  • 4Pennacchio LA, Olivier M, Hubacek JA, et al. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet, 2002, 11: 3031-3038.
  • 5Dallongeville J, Cottel D, Wagner A, et al. The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides. BMC Med Genet, 2008, 9:84.
  • 6Matsunaga A, Arishima H, Niimura H, et al. Strong linkage disequilibrium and association of -1131 T/C and e. 553G>T polymorphisms of the apolipoprotein a5 gene with hyper triglyeeridemia in a Japanese population. Circulation J, 2007, 71, 746- 752.
  • 7Lai CQ, Demissie S, Cupples LA, et al. Influence of the APOA5 locus on plasma triglyceride, lipoprotein subclasses, and CVD risk in the Framingham Heart Study. J Lipid Res, 2004, 45: 2096-2105.
  • 8Tang Y, Sun P, Guo D, et al. A genetic variant c. 553G>T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population. Atherosclerosis, 2006,185:433 -437.
  • 9Jang Y, Paik JK, Hyun YJ, et al. The apolipoprotein A5 -1131T>C promoter polymorphism in Koreans: association with plasma APOA5 and serum triglyeeride concentrations, LDI. particle size and coronary artery disease. Clin Chim Acta, 2009, 402: 83-87.
  • 10Talmud PJ, Hawe E, Martin S, et al. Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum Mol Genet, 2002,11 : 3039-3046.

二级参考文献11

  • 1Nabika T, Nasreen S, Kobayash S, et al. The genetic effect of the apoprotein AⅤ gene on the serum triglyceride level in Japanese. Atherosclerosis,2002,165:201-204.
  • 2Baum L, Tomlinson B, Thomas GN. APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men. Clin Genet, 2003,63:377-379.
  • 3Endo K, Yanagi H, Araki J, et al. Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren. Hum Genet,2002,111:570-572.
  • 4Martin S, Nicaud V, Humphries SE , et al. Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges. Biochim Biophys Acta,2003,1637:217-225.
  • 5Pennacchio LA, Olivier M, Hubacek JA, et al. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Science,2001,294:169-173.
  • 6van der Vliet HN, Sammels MG,Leegwater AC, et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J Biol Chem, 2001,276:44512-44520.
  • 7Pennacchio LA, Rubin EM. Comparative genomic tools and databases: providing insights into the human genome. J Clin Invest, 2003,111:1099-1106.
  • 8Aouizerat BE,Kulkarni M, Heilbron D, et al. Genetic analysis of a polymorphism in the human apo A-V gene: effect on plasma lipids. J Lipid Res,2003,44:1167-73.
  • 9Ribalta J, Figuera L, Fernandez-Ballart J, et al. Newly identified apolipoprotein AⅤ gene predisposes to high plasma triglycerides in familial combined hyperlipidemia. Clin Chem,2002,48:1597-1600.
  • 10Pennacchio LA, Olivier M, Hubacek JA, et al. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet,2002,11:3031-3038.

共引文献20

同被引文献34

  • 1丁妍,朱名安,周有利,王治校,杨公利.湖北汉族人群载脂蛋白A5遗传多态性分析[J].遗传,2007,29(5):554-558. 被引量：5
  • 2ZHAO T, ZHAO J. Association of the apolipoprotein A5 gene --t131 T> C polymorphism with fasting blood lipids: a meta-analysis in 37859 subjects[J]. BMC Med Genet,2010,11:120-120.
  • 3SANCHEZ-MORENO C, ORDOVAS J M, SMITH C E, et al. APOA5 gene variation interacts with diet- ary fat intake to modulate obesity and circulating tri- glycerides in a mediterranean population[J]. J Nutr, 2011,141 : 380-385.
  • 4LEE K H, KIM O Y, LIM H H, et al. Contribution of apoA5-1131C allele to the increased susceptibility of diabetes mellitus in association with higher triglyc- eride in Korean women[J]. Metabolism, 2010, 59: 1583-1590.
  • 5BINDER A. Identification of genes for a complex trait: examples from Hypertension[J]. Curt Pharm Biotechnol, 2006, 7: 1-13.
  • 6MONDRY A, LOH M, LIU P, et al. Polymorphisms of the insertion/deletion ACEand M23 5T AGT genes and hypertension: surprising new findings andmeta-anal- ysis of data[J]. BMC Nephrol, 2005, 6: 1-4.
  • 7VAN DER VLIET H N, SCHAAP F G, LEVELS J H, et al. Adenoviral Verexpressionof apolipoproteion A, V reduces serum levels of triglycerides andcholes- terol in mice[J]. Biochem Biophys Res Commun, 2002, 295: 1156-1159.
  • 8PENNACCHIO L A, OLIVIER M, HUBACEK J A, etal. Two independent Apolipoprotein A5 haplo- types influence human plasma triglyceride levels[J]. Hum Mol Genet, 2002, 11: 1-303.
  • 9靳钰,王奕,刘志强,等.醛固酮合酶基因-344T/C多态性与心房颤动的相关性研究[J].中外健康文摘,2012,7(37):59-60.
  • 10VU-DAC N, GERVOIS P, JAKEL H, et al. Apoli- poprotein A5, a crucial determinantof plasma triglyc- eride levels, is highly responsive to peroxisomeprolif- erator-activated receptor alpha activators[J]. J Biol Chem, 2003, 278: 17982-17985.

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中华医学遗传学杂志
2011年 第1期

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