摘要
猪传染性胃肠炎是由猪传染性胃肠炎病毒(TGEV)引起猪的一种高度接触性肠道疾病,可导致仔猪发生严重的呕吐、腹泻与脱水,死亡率可达100%。口服疫苗是TGEV基因工程疫苗研究的主要方向,目前已在腺病毒、细菌、转基因植物及DNA疫苗中对TGEV的S基因进行了表达,并对其口服免疫后的免疫原性进行研究。现针对TGEV基因工程疫苗近年来研究的概况进行综述,分析其优点与不足,并对其未来的发展进行展望。
Porcine transmissible gastroenteritis is a highly contagious,enteric disease of swine caused by transmissible gastroenteritis virus（TGEV）.The disease is especially severe in baby pigs less than two weeks old,characterized by vomiting,severe diarrhea,and nearly 100% mortality.New developments of TGEV genetic engineering vaccine have focused on production and delivery of the S protein through oral immunization.At present,several systems such as adenovirus,bacteria,transgenic plant,and DNA vaccine have been used to express the TGEV S proteins.After oral immunization,the immunogenicity of these vaccines has been studied.The research progress of TGEV genetic engineering vaccine were reviewed in this article,its advantage,disadvantage and further development were also prospected.
出处
《生物技术通报》
CAS
CSCD
北大核心
2011年第2期28-32,共5页
Biotechnology Bulletin
基金
云南省自然科学基金项目(2010ZC058)
关键词
猪传染性胃肠炎病毒
基因工程疫苗
口服免疫
Transmissible gastroenteritis virus Genetic engineering vaccine Oral immunization
