摘要
目的探讨医院大肠埃希菌的感染现状和耐药性,为临床医师诊断和治疗感染性疾病提供科学依据。方法按照《全国临床检验操作规程》采用常规方法进行菌株的分离鉴定;采用美国临床实验室标准化研究所推荐的K-B法进行药物敏感试验和评价结果。结果 260株大肠埃希菌对常用抗菌药物均产生了不同的耐药性,其中,对氨苄西林耐药率最高,达90.4%,对碳青霉烯类抗菌药物亚胺培南敏感率为100.0%;产超广谱β-内酰胺酶(ESBLs)大肠埃希菌的检出率为35.0%。结论医院大肠埃希菌的耐药性已十分严重,应加强合理使用抗菌药物管理,严格控制耐药菌的产生和流行。
OBJECTIVE To approach the infection status and drug resistance of Escherichia coli,to provide the scientific evidence for clinical diagnosis and treatment of infective diseases.METHODS Pathogenic bacteria were isolated and identified by routine methods according to the National Guide to Clinical Laboratory Procedures.Drug susceptibility testing was performed by K-B methods recommended by CLSI.RESULTS The different drug resistance to commonly used antibiotics occurred in 260 strains of E.coli.The drug resistant rate to ampicillin（90.4%） was the highest.No strain was resistant to carbapenems such as imipenem.The detection rate of extended spectrum β-lactamase（ESBLs） producer was 35.0%.CONCLUSION The drug resistance of E.coli is very serious.The management of antibiotics should be strengthened and the occurrence and prevalence of the drug resistant strains should be strictly controlled.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2011年第3期568-569,共2页
Chinese Journal of Nosocomiology
关键词
大肠埃希菌
医院感染
耐药性
超广谱Β-内酰胺酶
Escherichia coli
Nosocomial infection
Drug resistance
Extended spectrum β-lactamase
