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白细胞介素28B的基因多态性与丙型肝炎病毒感染转归的关系 被引量：11

Association of interleukin 28B(IL28B) polymorphisms with the outcomes of HCV infection
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摘要 丙型肝炎病毒(HCV)急性感染的患者,大约30%发生自发清除,已经进展为慢性丙型肝炎(CHC)的患者,经过抗病毒治疗,大约40%得到持久的HCV清除。近年来宿主基因变异在HCV感染治疗中的关键作用备受瞩目。今就近期的国内外报道,对白细胞介素(IL)28B的基因变异与HCV感染转归的关系进行综述。 Hepatitis C Virus（HCV） infection is spontaneously resolved in about 30% of acutely infected individuals.In those who progress to chronic hepatitis,HCV therapy permanently eradicates infection in about 40% of cases.It has long been suspected that host genetic factors are key determinants for the control of HCV infection.In this study,we will review the relationship between genetic variation in interleukin 28B（IL28B） and the control of HCV infection.
作者 石晓东 姜晶 牛俊奇
机构地区 吉林大学白求恩第一医院肝胆胰内科 吉林大学白求恩第一医院临床流行病学研究中心
出处 《临床肝胆病杂志》 CAS 2011年第1期28-31,共4页 Journal of Clinical Hepatology
关键词 肝炎 丙型 白细胞介素类 多态现象 遗传 hepatitis C interleukins polymorphism, genetic
分类号 R512.63 [医药卫生—内科学]
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参考文献22

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二级参考文献9

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共引文献12

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临床肝胆病杂志
2011年 第1期

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