摘要
川楝素(toosendanin)是从楝属植物的根茎及川楝果实(川楝子)中提取的一种三萜化合物。经研究证明其通过影响K+、Ca2+通道活性作用于神经系统、呼吸系统、神经肌肉接头及消化系统。近年来研究证明其通过诱导细胞分化及凋亡从而具有抗肿瘤作用,本文综述了川楝素的抗肿瘤作用及机制,为临床开发应用提供参考。
Toosendanin,a triterpenoid extracted from the root,stalk and fruit of Melia toosendan Sieb et Zucc.It had found that toosendanin could influence the activity of K＋ channels and Ca2＋ channels,then effected the nervous system,respiratory system,neuromuscular junction and digestive system.Recent researches report that toosendanin plays an important role in anti-tumor by induce cancer cells differentiation and apoptosis.The effects and mechanisms of toosendanin are demonstrated on cancer cells,in order to provide some evidences for fundamental research and further study.
出处
《科学技术与工程》
2011年第2期281-285,共5页
Science Technology and Engineering
基金
国家科技重大专项"重大新药创新"综合性新药研究开发技术大平台(2009ZX09301-002)
国家自然科学基金项目(81072613)资助
