摘要
目的观察舒洛地特联合贝那普利治疗糖尿病肾病的临床疗效。方法选择糖尿病肾病患者45例,随机分为对照组22例和治疗组23例。对照组在常规治疗的基础上加用贝那普利,治疗组在对照组的基础上加用舒洛地特,8周后测定2组患者空腹血糖、24 h尿蛋白、纤维蛋白原(FIB)、尿β_2-微球蛋白(β_2-MG)、血清果糖胺,并比较分析。结果 2组FBG无明显变化,与治疗前比较,2组24 h尿蛋白均降低,FIB仅治疗组降低。与对照组比较,治疗组患者24 h尿蛋白、FIB、尿β_2-MG、果糖胺均降低(P<0.05,P<0.01)。结论舒洛地特联合贝那普利可更有效改善糖尿病肾病患者的肾功能。
Objective To investigate the effects of combination therapy of sulodexide and benazapril in patients with diabetic kidney disease（DKD）.Methods Forty-five patients with DKD were randomly divided into control group（n =22） and treatment group（n = 23）.The control group was treated with benazapril,and the treatment group received the combination therapy of benazapril and sulodexide.After 8 weeks,fasting blood glucose（FBG）,24h urine protein,fibrinogen（FIB）, urineβ_2 -microglobulin（β_2-MG） and fructosamine were measured and compared between the two groups.Results The value of FBG didn＇ t changed obviously in the two groups.Compared with pre-treatment,the levels of 24h urine protein were decreased in both of the two groups.FIB was decreased only in treatment group.Compared with control group,the levels of 24h urine protein,FIB,β_2-MG and fructosamine were decreased in treatment group（P0.05,P0.01）.Conclusion Sulodexide combined with benazapril can improve renal function in patients with DKD.
出处
《疑难病杂志》
CAS
2011年第1期21-22,共2页
Chinese Journal of Difficult and Complicated Cases
