摘要
目的系统评价湿润烧伤膏治疗压疮的有效性。方法计算机检索PubMed、EMbase、Cochrane数据库、中国生物医学文献数据库(CBM)、维普资讯中文科技期刊数据库(VIP),均从建库检索至2010年5月,并筛选已获文献的参考文献,纳入比较湿润烧伤膏治疗与常规治疗压疮的随机对照试验(RCT)。由2名评价员独立进行质量评价和数据提取,采用RevMan 5.0.2软件进行Meta分析。结果共纳入11个RCT,合计703例患者。Meta分析结果显示,相对于常规治疗湿润烧伤膏可显著提高压疮的治愈率(OR=9.06,95%CI为6.21~13.21;P<0.01)和缩短治愈时间(MD=-8.11,95%CI为-12.39^-3.83;P<0.01)。结论现有证据表明湿润烧伤膏治疗压疮有效,但由于纳入研究的方法学质量较低,上述结论在临床使用时应谨慎考虑。
Objective To systematically evaluate the effect of Moist Exposed Burn Ointment（MEBO） on pressure ulcers.Methods By searching PubMed,EMbase,Cochrane database,Chinese BioMedicine database（CBM） and VIP Chinese Science and Technology Periodical Database（VIP）,we retrieved papers published by May of 2010,and sifted through all the references of retrieved papers for randomized controlled trials（RCTs） in which the effect of MEBO on pressure ulcers and the effect of conventional methods were compared.Two reviewers were assigned to independently appraise the quality of the research and extract the data by using Revman 5.0.2 for statistical analysis.Results Eleven RCT that involved a total of 703 patients were recruited.Meta-analysis shows that MEBO treatment were associated with a significantly higher cure rate of pressure ulcers（OR=9.06,95%CI：6.21-13.21;P0.01） and shorter healing time,as compared with conventional therapy（MD=-8.11,95%CI：-12.39——3.83;P0.01）.Conclusion MEBO is effective in treatment of pressure ulcers.However,these results need to be interpreted with caution provided that the quality of the included researches is less satisfactory.
关键词
湿润烧伤膏
美宝
压疮
荟萃分析
系统评价
循证医学
Moist Exposed Burn Ointment
MEBO
pressure ulcers
meta-analysis
systematic review
evidence-based medicine
