摘要
目前HBV可分为A~H8种基因型,基因型可分出亚型,HBV基因型及基因亚型呈现显著的地理区域性分布。感染基因型C比B的患者有更高的基因变异率、更高的HBV DNA滴度、更严重的肝损害、更低的抗病毒应答率,HBV基因型与肝细胞癌(HCC)相关。
Eight hepatitis B virus(HBV) genotypes(A ~ H) have been identified so far.Genotypes have been separated into subgenotypes,HBV genotypes and subgenotypes have distinct geographical distributions.Infection with subgenotype C is more frequently associated with HBV mutations,high viral load,severe liver damage,and lower rates of response to antiviral therapy than genotype B.HBV genotypes are associated with the risk of Hepatocellular carcinoma(HCC).
出处
《临床医学工程》
2011年第1期150-151,共2页
Clinical Medicine & Engineering
基金
广西壮族自治区卫生厅重点科研课题项目"HBV免疫症候与HBV基因型相关性研究"(编号:重200978)
关键词
乙型肝炎病毒
基因型
肝细胞癌
Hepatitis B virus(HBV)
Genotypes
Hepatocellular carcinoma(HCC)