摘要
目的探讨姜黄素对糖尿肾病大鼠肾功能及肿瘤坏死因子(TNF-α)、单核细胞趋化蛋白-1(MCP-1)的作用。方法制作糖尿病肾病模型大鼠,随机分为对照组及治疗组,比较各组的血生化、尿微量白蛋白排泄量(UAER)、TNF-α及MCP-1水平。结果模型大鼠内生肌酐清除率(Ccr)、UAER较正常鼠增多,血清肿瘤坏死因子-α升高,血清MCP-1明显升高;姜黄素治疗能明显降低Ccr(P<0.05),减少ALB排泄量(P<0.05),降低MCP-1(P<0.05)。结论姜黄素对糖尿病肾病具有明显疗效,其机制至少部分是通过拮抗TNF-α的作用,减少MCP-1的分泌,从而抑制肾脏炎症反应。
Objective：To explore the therapeutic effects of curcumin on TNF-α,MCP-1 and renal function of diabetic nephropathy rats.Methods： Diabetic nephropathy rats were randomly divided into the control group and the treatment group.Some indices were compared including the blood biochemical parameters,the 24h urinary albumin excretion,the serum TNF-α and the serum MCP-1.Results： Compared with normal rats,the Ccr and the urinary albumin excretion were increased markedly in diabetic nephropathy rats.Meanwhile,their serum TNF-αand MCP-1 were decreased.After treated with the curcumin,the Ccr,the urinary albumin excretion and the MCP-1 in these rats were decreased obviously.Conclusion： Curcumin has therapeutic effects on diabetic nephropathy.The mechanism is,at least in part,inhibition the inflammatory reaction through down-regulation of serum TNF-αand decrease secretion of MCP-1.
出处
《中国中医急症》
2011年第1期98-99,共2页
Journal of Emergency in Traditional Chinese Medicine
