摘要
目的：探讨抗退饮解热机制。方法：建立家兔ＬＰ 发热模型，观察抗退饮灌胃对家兔体温的影响和用放射免疫分析法检测腹 中隔ＡＶＰ 含量及下丘脑ｃＡＭＰ 含量的变化。结果：（１） 抗退饮灌胃＋ 静注ＬＰ 组的△Ｔ 为（０－５１ ±０－２５） ℃、中隔区ＡＶＰ 含量为（１１－９５ ±４－５２） ｐｇｍｇ 、下丘脑ｃＡＭＰ 含量为（０－９１３ ±０－４５０） ｐｍｏｌｍｇ 、分别低于ＮＳ 灌胃＋ 静注ＬＰ 组的△Ｔ（１－１８ ±０－２７） ℃、中隔区ＡＶＰ 含量（２２－３７ ±３－５８） ｐｇｍｇ 、下丘脑ｃＡＭＰ 含量（１－５６２ ±０－３６０） ｐｍｏｌｍｇ（ Ｐ＜０－０１） 。（２） 中隔区ＡＶＰ 含量变化与体温变化呈明显正相关（ｒ ＝ ０－７８２ ，Ｐ＜ ０－０１） 。结论：抗退饮解热机制可能是通过抑制下丘脑ｃＡＭＰ 含量升高，同时促进腹中隔ＡＶＰ
AIM:To explore the mechanisms of anti-virus defervescent decoction(AVDD,KTY) decreasing leucocytic pyrogen (LP) induced fever and the normal body temperature in rabbits. METHOD:The LP-induced fever model was established in rabbits. Fever response of rabbits was observed and the arginine vasopressin (AVP) content in the ventral septal area (VSA) and cAMP content in hypothalamus (HP) were determined by radioimmunoassay following stomach infusion of AVDD.RESULTS:(1)In AVDD and LP group, the △T was(0.51±0.25)℃, AVP content in VSA was (11.95±4.52) pg/mg, cAMP content in HP was (0.91±0.45) pmol/mg. In NS and LP group, they were (1.18±0.27)℃, (22.37±3.58) pg/mg and (1.56±0.36) pmol/mg, respectively. So the result of NS and LP group was superior to that of AVDD and LP group( P <0.01). (2)The AVP content in VSA paralleled with the fluctuation of temperature ( r =0.782, P <0 01).CONCLUSION:The mechanisms of AVDD in decreasing fever were probably by inhibited the increasing of cAMP content in HP, and meanwhile promoted the releasing of AVP content in VSA.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1999年第8期753-755,共3页
Chinese Journal of Pathophysiology
关键词
发热
CAMP
AVP
中医药疗法
抗退饮
家兔
Medicine
Chinese traditional
Fever
Adenosine cyclic monophosphate
Argipressin
Pyrogens
