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食管癌患者放疗前后血清转化生长因子β_1的变化及临床意义 被引量:4

The clinic significance of the changes of serum transforming growth factor 1 before and after radiotherapy in esophageal carcinoma patients
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摘要 目的探讨食管癌放疗前后血清转化生长因子β1(TGFβ1)水平改变与放疗疗效及预后的关系。方法:采用ELISA方法检测56例明确诊断的食管癌患者放疗前后的血清TGFβ1水平,并将其与病变范围、部位、X线病理分型、近期疗效及转移复发的关系进行对比分析。结果:放疗前食管癌患者血清TGFβ1平均水平明显高于正常对照组(P<0.01),血清TGFβ1的表达与病变部位、病变长度、X线病理分型无关(P>0.05);放疗后血清TGFβ1水平下降(P<0.05),其改变与近期疗效及转移复发相关(P<0.01)。结论:血清TGFβ1水平可作为监测食管癌近期放疗疗效和预后、提示后续或辅助治疗的一项参考指标。 Objective: To evaluate the relation between the changes of serum transforming growth factor beta1 (TGF1) and response to radiotherapy in esophageal carcinoma before and after radiotherapy. Methods: Fifty six newly diagnosed esophageal carcinoma patients were studied. Serum samples for TGF1 were obtained before and after radiotherapy. An enzymelined immunosorbent assay(ELISA) was used to measure changes of serum TGF1 levels and compared with the limits, location, Xray pathologic, the immediate response to radiotherapy, metastasis and recurrence. Results: The data showed that the serum TGF1 level in esophageal carcinoma patients before radiotherapy was significantly higher than that of healthy controls(P<0.01).The changes of serum levels after radiotherapy were also closely related to the limits, the immediate response to radiotherapy and metastasis and recurrence(P<0.01), but were not related to the location, Xray pathological pattern of the lesions. Conclusion: These results suggest that the serum TGF1 level may be a useful marker for monitoring the response and prognosis after radiotherapy in patients with esophageal carcinoma.
出处 《第二军医大学学报》 CAS CSCD 北大核心 1999年第7期471-473,共3页 Academic Journal of Second Military Medical University
关键词 食管肿瘤 放射疗法 TGFΒ1 血清 预后 esophageal neoplasms transforming growth factor beta1 radiotherapy
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