摘要
采用自由基聚合法在水溶液中制备了温敏水凝胶聚N-异丙基丙烯酰胺(PNIPAAm),以非水溶性药物布洛芬(IBU)为模型药物分子,研究了该水凝胶的温敏性能及与药物IBU的相互作用,考察了不同温度下(25℃和37℃)IBU在磷酸盐缓冲溶液(PBS,pH=7.4)中的释放行为。研究结果表明:该水凝胶的最低临界溶解温度(LCST)约为33 ℃,并且与IBU存在分子间氢键作用;当温度(37 ℃)高于凝胶的LCST时,IBU在pH=7.4的PBS溶液中释放的较慢,5 h内仅释放了~10%的药物;当温度(25 ℃)低于其LCST时,IBU释放的较快,5 h内释放了~42%的药物。因此,PNIPAAm水凝胶对IBU的释放具有温度控制性能。
Thermo-sensitive poly(N-isopropylacrylamide)(PNIPAAm) hydrogel was prepared by free-radical in water.With hydrophobic ibuprofen(IBU) as mode drug,the thermo-sensitive property of PNIPAAm and interaction with IBU were studied.The IBU release behavior was investigated in phosphate buffer solution(PBS,pH 7.4) at different temperatures(25 ℃ and 37 ℃).It was found that a lower critical solution temperature(LCST) of PNIPAAm around 33 ℃ and interacted with IBU by intermolecular hydrogen bond.The IBU released slower at 37 ℃(above LCST) than at 25 ℃ (bellow LCST) in PBS.Therefore,the release of IBU from the thermo-sensitive PNIPAAm hydrogel could be controlled by changing the temperature around LCST.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2011年第1期41-45,共5页
Chemical Research and Application
基金
河南省教育厅自然科学(2010B150032)研究项目
周口师范学院青年科研基金(zkqn200902)资助