摘要
目的 探讨ACA,Hcy,FA及VitB12与脑梗死的关系及临床应用价值.方法 采用ELISA及化学发光免疫分析技术,对66例脑梗死患者血清的ACA,Hcy,FA及VitB12进行检测并与30例健康对照者进行比较.结果 高Hcy血症在脑梗死患者中所占比率显著高于健康对照组（P＜0.01）;脑梗死患者Hcy浓度为（22.68±12.70 μmol/L）,明显高于健康对照组（13.38±2.61 μmol/L）,差异有统计学意义（P＜0.01）.脑梗组维生素B12（313.30±159.85 pg/ml）水平明显低于健康对照组（519.37±437.57 pg/ml）（P＜0.01）;叶酸（3.87±2.02 ng/ml）水平与健康对照组（8.23±3.28 ng/ml）也具有显著性差异（P＜0.05）;脑梗死高Hcy血症患者其Hcy水平（27.36±12.90 μmol/L）显著高于脑梗死Hcy正常者（12.65±1.85 μmol/L）和健康对照组,差异有统计学显著性意义（P＜0.01）,但维生素B12和叶酸的水平差异则无统计学显著性意义（P＞0.05）.脑梗死Hcy正常患者Hcy,FA及VitB12水平与健康对照组比较差异均无统计学显著性意义（P＞0.05）;脑梗死患者ACA的检出率为53.03%,与健康对照组比较差异有统计学显著性意义（P＜0.01）.结论 高Hcy血症是脑梗死发病的独立危险因素.叶酸和Vit B12 缺乏可能是导致高Hcy血症的重要原因.脑梗死发病与ACA关系密切,ACA可能参与脑血管病变的发病过程.
Objective To explore the relationship between cerebral infarction and the serum levels of Anti-cardiolipin antibodies（ACA）,homocysteine（Hcy）,folate（FA） and vitamin B12（VitB12）.Methods To mensurate the ACA using ELISA methods. The serum levels of Hcy, FA and VitB12 in 66 patients of cerebral infarction were measured by chemiluminescence immunoassay （CLIA） and compared with those of 30 cases in healthy controls. Results The positive rate of hyper-homocysteinemia（HHcy） in cerebral infarction patients were 68.18%. There was significant difference compared with the healthy controls （P^0.01）. The serum Hcy levels in patients of cerebral infarction were significantly higher than those （22.68±12.70 μmol/L） compared with healthy controls （13.38±2.61 μmol/L）（P〈0.01）;whereas the VitB12 levels（313.30±159.85 pg/ml） （P〈0. 01） were significantly lower and FA levels（3.87±2.02 ng/ml） between has markable difference （P〈0.05） than those in healthy controls. HHcy levels in patients of cerebral infarction were （27.36±12.90 μmol/L） with significantly higher than those in the normal serum level of homocysteine（non-HHey）in cerebral infarction patients （12.65±1.85 μmol/L） and healthy controls （P〉0.05）. There was no significant difference of serum levels of Hcy,FA and VitB12 in the normal serum level of homocysteine （non-HHcy） in cerebral, infarction patients and healthy controls. The sitive rate of ACA in cerebral infarction patients were 53.03%. There was significant difference com- pared with the healthy controls （P〈0.01）. Conclusion The high serum level of Hcy is an independent risk factor for cerebral infarction. The deficiency of FA and Vit B12 may be an important factor for HHcy. ACA seem to behave as risk factors for cerebral infarction patients which may contribute to the process of vascular disease in patients with cerebral infarction.
出处
《现代检验医学杂志》
CAS
2010年第6期40-43,共4页
Journal of Modern Laboratory Medicine
