摘要
目的：探讨血清前列腺特异性抗原（PSA）与前列腺癌（PCa）临床分期、病理分级的相关性。方法：对自2004年7月~2009年12月南京市13692例50岁以上的男性在健康体检时行血清PSA检测。以PSA≥4.0ng/ml定为前列腺癌可疑病例。建议行前列腺穿刺活检以确诊。共筛查出PCa患者140例,比较不同PSA值PCa患者的Gleason评分及临床分期。结果：随着PSA值的升高,前列腺癌筛查阳性率亦随之升高,低分化前列腺癌患者血清PSA含量明显高于高分化前列腺癌和中分化前列腺癌患者（P〈0.05）,晚期前列腺癌患者血清PSA含量明显高于早期PCa患者（P〈0.01）。血清PSA含量≥20ng/ml的前列腺癌人群中低分化前列腺癌及晚期前列腺癌的比例高于血清PSA含量〈20ng/ml的前列腺癌人群（P〈0.01）。结论：血清PSA可以为前列腺癌患者的诊断、治疗及预后判断提供重要依据。
Objective：To investigate the relationship between clinical stage,pathology grade of prostate cancer and serum PSA.Methods：Between July 2004 and December 2009,the serum PSA of 13692 males over 50-years old for health examination was evaluated.And 140 cases were diagnosed as prostate cancer,compared gleason score and clinical stages in terms of PSA level.Results：It was found that the percentage of prostate cancer,increased with the PSA value.The serum PSA value in poorly differentiated prostate cancer was significantly higher than that in well-differentiated prostate cancer or moderately differentiated prostate cancer,and the serum PSA value was significantly different between early stage prostate cancer and advanced stage prostate cancer.Conclusions：Serum PSA is important to the diagnosis,treatment and prognosis of prostate cancer.
出处
《现代生物医学进展》
CAS
2010年第23期4544-4546,共3页
Progress in Modern Biomedicine
关键词
前列腺癌
前列腺特异性抗原
临床分期
病理分级
Prostate cancer
Prostate specific antigen
Clinical stage
Pathological grade
