摘要
目的:探讨非典型抗精神病药阿立哌唑与齐拉西酮对精神分裂症患者血糖、血清C-肽水平、血脂的影响。方法:将60例精神分裂症患者随机分为两组,分别给予阿立哌唑与齐拉西酮治疗,于入院时及治疗后4周、治疗后8周采用全自动生化仪分别检测空腹血糖、血清C-肽、胆固醇(TC)、甘油三脂(TG)水平,并对测定结果进行分析。结果:阿立哌唑组、齐拉西酮组组间血糖、血清C-肽及TC、TG于治疗4周末及治疗8周末比较,均无显著性差异(P>0.05)。阿立哌唑组、齐拉西酮组同组间比较,治疗前后上述指标无显著性差异(P>0.05)。阿立哌唑、齐拉西酮两组血糖、血清C-肽与TC、TG在治疗前后变化无相关性。结论:阿立哌唑、齐拉西酮对精神分裂症患者血糖、血脂代谢无明显影响。
Objective：To investigate the effect of aripiprazole and ziprasidone on the blood-glucose,C-peptide and serum lipid levels in patients with schizophrenia.Methods：Sixty schizophrenic patients were divided into two groups,and given aripiprazole and ziprasidone,respectively.The levels of fasting blood glucose,C-peptide,cholesterol（TC） and triglyceride（TG） were determinated by automatic biochemical analyzer at baseline,4 weeks and 8 weeks after the treatment,and the data were analyzed statistically.Results：There were no significant differences between the two groups on the blood-glucose,C-peptide and serum lipid levels at 4 weeks and 8 weeks after the treatment（P 0.05）.The blood-glucose,C-peptide,serum lipid levels did not change significantly before and after the treatment in two groups（P 0.05）,and the changes of these indexes were not correlative.Conclusion：There were no effect of aripiprazole and ziprasidone on serum glucose and lipid metabolism.
出处
《中国药物应用与监测》
CAS
2010年第6期330-331,334,共3页
Chinese Journal of Drug Application and Monitoring
