摘要
目的:探讨泌尿系神经内分泌癌(NEC)的临床特点、病理特征和诊断治方法。方法:回顾性分析24例泌尿系NEC患者的临床资料,其中发生于腹膜后1例,肾上腺1例,肾盂2例,输尿管2例,膀胱15例,精囊1例,前列腺2例。男14例,女10例,年龄16～83岁,平均59岁。结果:经病理检查证实为NEC,免疫组织化学表达嗜铬粒蛋白(CgA)17例,神经特异性烯醇化酶(NSE)19例,腺癌突触素(Syn)6例。采用综合疗法,目前生存12例,最长9年6个月;死亡12例,均在术后1年内死亡。结论:泌尿系NEC临床罕见,确诊需行免疫组织化学或电镜检查;治疗以手术切除联合放化疗为宜,但预后较差。
Objective：To study the diagnosis and management of neuroendocrine carcinoma in urology. Methods：Clinical data of 24cases of neuroendocrine carcinoma in urology were reviewed. The distribution of original sites was suprarenal gland, renal plevis, utter, urinary bladder, prostate and seminal vesicle gland. Results： The pathological diagnosis was neuroendocrine carcinoma. Immunohistochemical examination showed that the tumors were stained for neuroendocrine markers such as chromogranin （CgA. 16 cases）, enolse （NSE. 18 cases） and synaptophysin （Syn. 6 cases）. Tweleve patients were under follow-up as far. Tweleve patients died of this disease. Conclusions： Neuroendocrine carcinoma is a rare and aggressive tumour with a poor prognosis. Future efforts should be directed at its early detection and the development of more effective systemic therapies.
出处
《临床泌尿外科杂志》
北大核心
2011年第2期124-126,共3页
Journal of Clinical Urology
关键词
神经内分泌癌
泌尿系
诊断
治疗
neuroendocrine carcinoma, urinary system
diagnosis
therapy
