期刊文献+

活性氧物质对骨髓造血功能的影响 被引量:13

原文传递
导出
摘要 活性氧物质(ROS)一般情况下是由体内正常的氧代谢产物形成,在细胞信号转导过程中起重要作用。细胞内适当水平的ROS在调控一些生物学现象中发挥着重要的作用,包括一些信号通路的激活以及这些信号所涉及的基因表达。然而,在各种因素的影响下,ROS生成增多和(或)正常细胞内抗氧化系统的损伤都会导致细胞的氧化应激反应,
作者 谢芳 赵明峰
出处 《中华血液学杂志》 CAS CSCD 北大核心 2011年第2期139-141,共3页 Chinese Journal of Hematology
  • 相关文献

参考文献27

  • 1Naka K,Muraguchi T,Hoshii T,et al.Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells.Antioxidants Redox Signaling,2008,10:1883-1894.
  • 2Kong Y,Zhou S,Kihm AJ,et al.Loss of alpha-hemoglobin stabilizing protein impairs erythropoiesis and exacerbates beta-thalassemia.J Clin Invest,2004,114:1457-1466.
  • 3Chen ZX,Pervaiz S.Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cells.Cell Death Differ,2007,14:1617-1627.
  • 4Orrenius S,Gogvadze V,Zhivotovsky B.Mitochondrial oxidative stress:implications for cell death.Annu Rev Pharmacol Toxicol,2007,47:143-183.
  • 5Pervaiz S,Taneja R,Ghaffari S.Oxidative stress regulation of stem and progenitor cells.Antioxidants Redox Signaling,2009,11:2777-2789.
  • 6Thannickal VJ,Fanburg BL.Reactive oxygen species in cell signaling.Am J Physiol Lung Gell Mol Physiol,2000,279:L1005-L1028.
  • 7Ghaffari S.Oxidative stress in the regulation of normal and neoplastic hematopoiesis.Antioxidants Redox Signaling,2008,10:1923-1940.
  • 8Owusu-Ansah E,Banerjee U.Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation.Nature,2009,461:537-541.
  • 9Barzilai A,Rotman G,Shiloh Y.ATM deficiency and oxidative stress:a new dimension of defective response to DNA damage.DNA Repair (Amst),2002,1:3-25.
  • 10Ito K,Hirao A,Arai F,et al.Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.Nat Med,2006,12:446-451.

同被引文献187

引证文献13

二级引证文献81

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部